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The effect of cystamine on gastric secretion in the rat

Agents and Actions volume 9, pages 248–252 (1979)Cite this article

Abstract

The effects of cystamine on gastric secretion were studied in conscious and anaesthetized rat preparations. In the conscious gastric fistula rat cystamine inhibited the basal acid output but increased pepsin output. This pepsinogogue action was inhibited by both atropine and metiamide. In the anaesthetized rat cystamine stimulated gastric acid output, an effect blocked by cimetidine which had an inhibitory E.D.50 which was not significantly different from that obtained against histamine-stimulated secretion in this preparation. Atropine at high doses failed to inhibit the response. Depletion of mast cell histamine by compound 48/80 and the removal of endogenous gastrin stores did not abolish the secretory response to cystamine. In the light of these results possible mechanisms of action for the secretagogue effects of cystamine are discussed.

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References

  1. H. Selye andS. Szabo,Experimental Model for Production of Perforating Duodenal Ulcer by Cysteamine in the Rat, Nature244, 458 (1973).

    PubMed  Google Scholar 

  2. A. Robert, J.E. Nezamis, C. Lancaster andJ.N. Badalamenti,Cysteamine-Induced Duodenal Ulcers: A New Model to Test Antiulcer Agents, Digestion11, 199 (1974).

    PubMed  Google Scholar 

  3. W.G. Groves, J.H. Schlosser andF.D. Mead,Acid Hypersecretion and Duodenal Ulcers produced by Cysteamine in Rats, Res. Comm. Chem. Path. Pharmac.9, 523 (1974).

    Google Scholar 

  4. Y. Ishii, Y. Fujii andM. Homma,Gastric Acid Stimulating Action of Cysteamine in the Rat, Eur. J. Pharmac.36, 331 (1976).

    Google Scholar 

  5. K.T. Bunce andM.E. Parsons,The Effect of Hexamethonium on Gastric Acid Secretion in the Conscious Rat, Agents and Actions7, 507 (1977).

    PubMed  Google Scholar 

  6. A. Lane, A.C. Ivy andE.K. Ivy,Response of the Chronic Gastric Fistula Rat to Histamine, Am. J. Physiol.190, 221 (1957).

    PubMed  Google Scholar 

  7. M.M. Vatier, A.M. Cheret andS. Bonfils,Le Dosage Automatique de l'Activité Proteolytique du Suc Gastrique, Biol. Gastroenterol.1, 15 (1968).

    Google Scholar 

  8. M.N. Ghosh andH.O. Schild,Continuous Recording of Acid Gastric Secretion in the Rat, Br. J. Pharmac. Chemother.13, 54 (1958).

    Google Scholar 

  9. M.E. Parsons,Quantitative Studies of Drug Induced Gastric Secretion, Ph.D. Thesis, University of London (1969).

  10. H. Robbers,Die Pharmakologische Wirkung des Cystamins, einer Blutdrucksen-kenden Substanz, Arch. Exptl. Pathol. Pharmacol.185, 461 (1937).

    Google Scholar 

  11. G.E. Demaree, R.L. Mundy, M.H. Heiffer andD.P. Jacobus,In Vitro Histamine Release from Rat Peritoneal Cells by β-Mercaptoethylamine and Cystamine, J. Pharmac. exp. Ther.144, 380 (1964).

    Google Scholar 

  12. R.L. Mundy, M.H. Heiffer andG.E. Demaree,Histamine Release by β-Mercaptoethylamine, Fedn. Proc.22, 424 (1963).

    Google Scholar 

  13. R.L. Mundy, G.E. Demaree, D.P. Jacobus andM.H. Heiffer,β-Mercaptoethylamine and Cystamine-Induced Histamine Release in the Dog, Arch. Int. Pharmacodyn.165, 64 (1967).

    PubMed  Google Scholar 

  14. J. Lecomte,Proprietes Pharmacodynamiques de la Cystinamine, Arch. Int. Physiol. Biochem.60, 179 (1952).

    Google Scholar 

  15. T.L. Fletcher, H.L. Buchman, A.W. Dahl, J.E. Jesseph andR.H. Larsen,Decreased Gastric Secretory Activity Following Injection of Certain Maleimides, β-Mercaptoethylamine, or the Combination of Both Types, J. Med. Chem.1, 275 (1959).

    Google Scholar 

  16. R.W., Brimblecombe, W.A.M. Duncan, G.J. Durant, J.C. Emmett, C.R. Ganellin andM.E. Parsons,Cimetidine — a Non-Thiourea H 2-Receptor Antagonist, J. Int. Med. Res.312, 86 (1975).

    Google Scholar 

  17. L.M. Lichtenberger, S. Szabo andJ.S. Trier,Duodenal Ulcerogens, Cysteamine and Propionitrile, Stimulate Serum Gastrin Levels in the Rat, Gastroenterology73, 1305 (1977).

    PubMed  Google Scholar 

  18. A.R. Hedges andM.E. Parsons,The Effect of Anaesthesia on the Inhibition of Pentagastrin-Evoked Gastric Acid Secretion Induced by Atropine in the Rat, J. Physiol.267, 181 (1977).

    PubMed  Google Scholar 

  19. L.E. Borella, K. Seethaler andW. Lippmann,The Role of Gastric Acid and Pepsin Secretion in the Formation of Cysteamine-Induced Duodenal Ulcers in Rats, in:Prog. Peptic Ulcer (Proc. Conf. Exp. Ulcer) (Eds. G. Moznik and T. Javor; Akad. Kaido, Budapest, Hung.), p. 585.

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Affiliations

  1. The Research Institute, Smith Kline & French Laboratories Ltd., Welwyn Garden City, Hertfordshire, England

    M. E. Parsons, K. T. Bunce, A. Currington, F. Matheson & G. Pipkin

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  1. M. E. Parsons
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  2. K. T. Bunce
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  3. A. Currington
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  4. F. Matheson
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  5. G. Pipkin
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Parsons, M.E., Bunce, K.T., Currington, A. et al. The effect of cystamine on gastric secretion in the rat. Agents and Actions 9, 248–252 (1979). https://doi.org/10.1007/BF01966696

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  • DOI: https://doi.org/10.1007/BF01966696

Keywords

  • Histamine
  • Cimetidine
  • Atropine
  • Gastric Secretion
  • Acid Output