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Inhibition of diamine oxidase by antihistaminic agents and related drugs

Agents and Actions volume 9, pages 244–247 (1979)Cite this article

Abstract

Various drugs were tested as inhibitors of diamine oxidase on the basis of chemical relationships to the enzyme substrates.

It was found that serotonine tryptamine and phenformin are good competitive inhibitors while cimetidine and pheniprazine are non-competitive inhibitors. Other antihistaminic drugs like promethazine are less powerful inhibitors.

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Authors and Affiliations

  1. Libero Istituto Universitario di Medicina e Chirurgia, L'Aquila ed Istituto di Chimica Biologica dell' Università di Cagliari, Italy

    Alessandro Finazzi-Agrò, Giovanni Floris, Maria Benedetta Fadda & Carlo Crifò

Authors
  1. Alessandro Finazzi-Agrò
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  2. Giovanni Floris
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  3. Maria Benedetta Fadda
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  4. Carlo Crifò
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Finazzi-Agrò, A., Floris, G., Fadda, M.B. et al. Inhibition of diamine oxidase by antihistaminic agents and related drugs. Agents and Actions 9, 244–247 (1979). https://doi.org/10.1007/BF01966695

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  • DOI: https://doi.org/10.1007/BF01966695

Keywords

  • Cimetidine
  • Diamine
  • Competitive Inhibitor
  • Tryptamine
  • Promethazine