Agents and Actions

, Volume 17, Issue 1, pp 53–59 | Cite as

The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid)

  • Steven C. Gilman
  • Richard P. Carlson
  • Joseph Chang
  • Alan J. Lewis
Immunosuppression and Inflammation


The antiinflammatory activity of the immuno-modulatory agent Wy-18,251 (3-(p-chlorophenyl)thiazolo-[3,2-a]benzimidazole-2-acetic acid) was examined using a variety of antiinflammatory, analgesic and antipyretic animal models in comparison to aspirin, levamisole and indomethacin. The acute antiinflammatory and analgesic activity of Wy-18,251 (ED50=100–200 mg/kg, p.o.) was similar to aspirin, but in contrast to aspirin Wy-18,251 failed to demonstrate antipyretic activity. Wy-18,251 (10–100 mg/kg, p.o.) also inhibited chronic inflammatory responses in the adjuvant- and collagen-induced arthritis models. Wy-18,251 was a modest inhibitor of prostaglandin biosynthesis but did not inhibit either 5- or 15-lipoxygenase enzymes. Wy-18,251 (up to 480 mg/kg, p.o.) produced little gastrointestinal pathology in 16 h fasted rats. The combined immunomodulatory and antiinflammatory activity of Wy-18,251 suggests that this agent may have therapeutic promise in certain immunoinflammatory diseases including rheumatoid arthritis.


Rheumatoid Arthritis Arthritis Aspirin Indomethacin Antiinflammatory Activity 
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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • Steven C. Gilman
    • 1
  • Richard P. Carlson
    • 1
  • Joseph Chang
    • 1
  • Alan J. Lewis
    • 1
  1. 1.Department of Experimental TherapeuticsWyeth Laboratories, Inc.PhiladelphiaUSA

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