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, Volume 17, Issue 1, pp 53–59 | Cite as

The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid)

  • Steven C. Gilman
  • Richard P. Carlson
  • Joseph Chang
  • Alan J. Lewis
Immunosuppression and Inflammation

Abstract

The antiinflammatory activity of the immuno-modulatory agent Wy-18,251 (3-(p-chlorophenyl)thiazolo-[3,2-a]benzimidazole-2-acetic acid) was examined using a variety of antiinflammatory, analgesic and antipyretic animal models in comparison to aspirin, levamisole and indomethacin. The acute antiinflammatory and analgesic activity of Wy-18,251 (ED50=100–200 mg/kg, p.o.) was similar to aspirin, but in contrast to aspirin Wy-18,251 failed to demonstrate antipyretic activity. Wy-18,251 (10–100 mg/kg, p.o.) also inhibited chronic inflammatory responses in the adjuvant- and collagen-induced arthritis models. Wy-18,251 was a modest inhibitor of prostaglandin biosynthesis but did not inhibit either 5- or 15-lipoxygenase enzymes. Wy-18,251 (up to 480 mg/kg, p.o.) produced little gastrointestinal pathology in 16 h fasted rats. The combined immunomodulatory and antiinflammatory activity of Wy-18,251 suggests that this agent may have therapeutic promise in certain immunoinflammatory diseases including rheumatoid arthritis.

Keywords

Rheumatoid Arthritis Arthritis Aspirin Indomethacin Antiinflammatory Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • Steven C. Gilman
    • 1
  • Richard P. Carlson
    • 1
  • Joseph Chang
    • 1
  • Alan J. Lewis
    • 1
  1. 1.Department of Experimental TherapeuticsWyeth Laboratories, Inc.PhiladelphiaUSA

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