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, Volume 17, Issue 2, pp 150–152 | Cite as

Anti-inflammatory effect of intraventricularly administered histamine in rats

  • S. K. Bhattacharya
  • Neeta Das
Histamine and Kinins

Abstract

Intracerebroventricularly (icv) administered histamine (5, 10 and 20 μg) produced a dose-related anti-inflammatory effect against carrageenin-induced pedal edema in rats. The effect of histamine was mimicked by the H1 receptor agonist, 2-methylhistamine, but not by the H2 receptor agonist, 2-methylhistamine, The anti-inflammatory effect of centrally administered histamine was antagonised by mepyramine, a H1 receptor antagonist, but not by cimetidine, a H2 receptor antagonist.

The anti-inflammatory effect of icv histamine was inhibited in bilaterally adrenalectomised rats but was unaffected by peripheral chemical sympathectomy induced by 6-hydroxydopamine.

Keywords

Receptor Antagonist Histamine Receptor Agonist Cimetidine Pedal Edema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • S. K. Bhattacharya
    • 1
  • Neeta Das
    • 1
  1. 1.Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical SciencesBanaras Hindu UniversityVaranasiIndia

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