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, Volume 21, Issue 3–4, pp 316–319 | Cite as

The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice

  • K. D. Rainsford


The findings presented in this report show that: (1) 5-lipoxygenase inhibitors and some leukotriene antagonists protect the gastric mucosa against lesions induced by oral or parenteral administration of most NSAIDs, with the possibility of some variation in effects with aspirin.

(2) These observations suggest that overproduction of leukotrienes and other products of 5-lipoxygenase activity may play a role in the development of acute gastric mucosal damage induced by NSAIDs.


Aspirin Antiinflammatory Drug Nonsteroidal Antiinflammatory Drug Gastric Mucosa Mucosal Damage 
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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • K. D. Rainsford
    • 1
  1. 1.Department of PharmacologyUniversity of CambridgeCambridgeEngland

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