The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice
- 62 Downloads
The findings presented in this report show that: (1) 5-lipoxygenase inhibitors and some leukotriene antagonists protect the gastric mucosa against lesions induced by oral or parenteral administration of most NSAIDs, with the possibility of some variation in effects with aspirin.
(2) These observations suggest that overproduction of leukotrienes and other products of 5-lipoxygenase activity may play a role in the development of acute gastric mucosal damage induced by NSAIDs.
KeywordsAspirin Antiinflammatory Drug Nonsteroidal Antiinflammatory Drug Gastric Mucosa Mucosal Damage
Unable to display preview. Download preview PDF.
- K. D. Rainsford,Mechanisms of gastric contrasted with intestinal damage by nonsteroidal antiinflammatory drugs. In:Side Effects of Antiinflammatory Drugs. Vol. II (Eds.: K. D. Rainsford and G. P. Velo) pp. 3–26. MIP Press, Lancaster 1987.Google Scholar
- J. R. Walker and J. Harvey,Actions of antiinflammatory drugs on leukotriene and prostaglandin metabolism: relationships to asthma and other hypersensitivity reactions. Inside effects of antiinflammatory/analgesic drugs. (Eds. K. D. Rainsford and G. P. Velo) pp. 227–238 Raven Press, New York 1984.Google Scholar
- S. M. Coutts, A. Khandwala, R. Van Inwegen, U. Chakraborty, J. Musser, J. Bruens, N. Jariwala, V. Dally-Meade, R. Ingram, T. Puss, H. Jones, E. Neiss and I. Weinryb,Arylmethyl phenyl ethers. A new class of specific inhibitors of 5-lipoxygenase. InProstaglandins, leukotrienes, and lipoxins. (Ed. J. M. Bailey) pp. 627–637 Plenum Press, New York 1985.Google Scholar
- Y. Guindon, Y. Girard, A. Maycock, A. W. Ford-Hutchinson, J. G. Atkinson, P. C. Belanger, A. Dallob, D. DeSousa, H. Dougherty, R. Egan, M. M. Goldenberg, E. Ham, R. Fortin, P. Hamel, R. Hamel, C. K. Lau, Y. Leblanc, C. S. McFarlane, H. Piechuta, M. Thérien, C. Yoakim and J. Rokach, L-651,392 a novel, potent and selective 5-lipoxygenase inhibitor. InAdvances in prostaglandins, thromboxane and leukotriene research. (Eds. B. Samuelsson et al.) pp. 554–557. Raven Press, New York 1987.Google Scholar
- T. R. Jones, R. Young, E. Champion, L. Charette, D. Denis, A. W. Ford-Hutchinson, R. Frenette, J.-Y. Gauthier, Y. Guindon, M. Kakushima, P. Masson, A. Maycock, C. McFarlane, H. Piechuta, J. Rokach and R. Zamboni,L-649,923, sodium (βS *,γR *)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl-thio)-γ-hydroxy-β-methylbenzenebutanoate, a selective, orally active leukotriene acceptor antagonist. Can. J. Physiol. Pharmacol.64, 1068–1075 (1986).PubMedGoogle Scholar
- J. Chang, personal communication.Google Scholar
- K. D. Rainsford,Gastric ulcerogenicity of non-steroidal anti-inflammatory drugs in mice with mucosa sensitized by cholinomimetic treatment. J. Pharm. Pharmacol., in press (1987).Google Scholar