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, Volume 21, Issue 3–4, pp 278–280 | Cite as

Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding

  • M. A. Iannone
  • G. Wolberg
  • R. Reynolds-Vaughn
  • T. P. Zimmerman
Antiinflammatory/Antiarthritic Agents


We have studied the effect of taxol on two N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced neutrophil functions and the possible mechanism by which it inhibits these functions. Taxol inhibited FMLP-induced human neutrophil polarization (a characteristic change in neutrophil shape in response to a chemotactic stimulus) and H2O2 generation. Taxol also decreased the specific binding of [3H]FMLP to human neutrophils at 4°C. The decreased binding of FMLP to its receptor may be responsible for the inhibition by taxol of FMLP-induced polarization and H2O2 generation.


H2O2 Specific Binding Taxol Human Neutrophil Characteristic Change 
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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • M. A. Iannone
    • 1
  • G. Wolberg
    • 1
  • R. Reynolds-Vaughn
    • 1
  • T. P. Zimmerman
    • 1
  1. 1.Wellcome Research LaboratoriesResearch Triangle ParkUSA

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