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, Volume 19, Issue 3–4, pp 233–243 | Cite as

Sustained release of a corticosteroid using polymeric implants

  • S. Cawley
  • D. J. Ormrod
  • J. W. Paxton
  • T. E. Miller
Immunosuppression and Inflammation


An effective sustained release method of drug administration, using methylprednisolone incorporated into acrylic bone cement, has been developed. The effect of this form of treatment on peripheral blood leukocytes, lymphoid tissue weight and the inflammatory response has been evaluated. This mode of methylprednisolone administration was compared with conventional systemic therapy and was found to produce rapid and prolonged pharmacological effects at very low plasma levels of drug. A dose response relationship was established and we determined that, for a given quantity of drug, the level and duration of suppression was greater using sustained release therapy. The inflammatory response was also depressed using this mode of administration. These results, coupled with the commercial availability and existing clinical approval of SIMPLEX P bone cement, suggest that further development may lead to useful clinical protocols.


Methylprednisolone Systemic Therapy Lymphoid Tissue Sustained Release Response Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this paper


bone cement




polymorphonuclear leukocyte


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  1. [1]
    J. R. Salaman,Steroids and modern immunosuppression. Brit. Med. J.286, 1373–1375 (1983).Google Scholar
  2. [2]
    C. Ponticelli, A. F. De Vecchi, A. Tarantino, E. Rivolta, F. M. Egidi, L. Berardinelli and A. Vegeto,A search for optimizing corticosteroid administration to renal transplant patients. Kidney Int.23, S85-S89 (1983).Google Scholar
  3. [3]
    A. P. Provoost, M. H. De Keijzer, W. J. Kort and E. D. Wolff,Superiority of continuous infusion of prednisolone over daily injections in the prolongation of heart allograft survival in rats. Transplantation34, 221–222 (1982).PubMedGoogle Scholar
  4. [4]
    J. H. Kehrl and A. S. Fauci,The clinical use of glucocorticoids. Ann. Allergy50, 2–8 (1983).PubMedGoogle Scholar
  5. [5]
    R. C. Haynes and F. Murad, Adrenocorticotropic hormone; Adrenocortical Steroids and their synthetic analogs; inhibitors of Adrenocortical steroid biosynthesis. InThe Pharmacological Basis of Therapeutics, pp. 1466–1496 (Eds. A. G. Gilman, L. S. Goodman and A. Gilman). Mac-Millan Publishing Co., New York 1980.Google Scholar
  6. [6]
    S. K. Chandrasekaran, H. Benson and J. Urquhart, Methods to achieve controlled drug delivery — The biomedical engineering approach. InSustained and Controlled Release Drug Delivery Systems, pp. 557–594 (Ed. J. Robinson). Marcel Dekker, New York 1978.Google Scholar
  7. [7]
    D. R. Cowsar, O. R. Tarwater and A. C. Tanquary, Controlled release of fluoride from hydrogels for dental applications. InHydrogels for Medical and Related Applications, pp. 180–197 (Ed. J. D. Andrade). ACS, Washington 1976.Google Scholar
  8. [8]
    R. H. Stewart and S. Novak,Introduction of the ocusert ocular system to an ophthalmic practice. Ann. Ophthal.10, 325–330 (1978).PubMedGoogle Scholar
  9. [9]
    G. Zador, B. A. Nilsson, B. Nilsson, N. O. Sjoberg, L. Westrom and J. Wiese,Clinical experience with the uterine progesterone system (Progestasert ®). Contraception13, 559–569 (1976).PubMedGoogle Scholar
  10. [10]
    L. R. Beck and V. Z. Pope,Controlled-release delivery systems for hormones. A review of their properties and current therapeutic use. Drugs27, 528–547 (1984).PubMedGoogle Scholar
  11. [11]
    D. J. Ormrod, S. Cawley and T. E. Miller,Extended immunosuppression with cyclophosphamide using controlled release polymeric implants. Int. J. Immunopharmacol.7, 443–448 (1985).PubMedGoogle Scholar
  12. [12]
    T. E. Miller and D. Ormrod,The anti-inflammatory activity of Perna canaliculus (NZ green lipped mussel). NZ Med. J.92, 187–193 (1980).Google Scholar
  13. [13]
    J. G. Kitrenos, M. Jones and D. C. McLeod,Comparison of selected intravenous infusion pumps and rate regulators. Am. J. Hosp. Pharm.35, 304–310 (1978).PubMedGoogle Scholar
  14. [14]
    K. R. Sidman, A. D. Schwope, W. D. Steber, S. E. Rudolph and S. B. Poulin,Use of synthetic polypeptides for biodegradable drug delivery systems. Polymer Preprints20, 27 (1979).Google Scholar
  15. [15]
    Y. W. Chien,Novel drug delivery systems. Marcel Dekker, New York 1982.Google Scholar
  16. [16]
    L. R. Beck and T. R. Tice, Poly(lactic acid) and poly(lactic acid-co-glycolic acid) contraceptive delivery systems. InLong-Acting Steroidal Contraception, pp. 175–188 (Ed. D. R. Mishell). Raven Press, New York 1983.Google Scholar
  17. [17]
    B. E. Ryman, R. F. Jewkes, K. Jeyasingh, M. P. Osborne, H. M. Patel, V. J. Richardson, M. H. N. Tattersall and D. A. Tyrrell,Potential applications of liposomes to therapy. Ann. N.Y. Acad. Sci.308, 281–307 (1978).PubMedGoogle Scholar
  18. [18]
    H. W. Buchholz and H. Engelbrecht,Über die Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos. Chirurg.41, 511–515 (1970).PubMedGoogle Scholar
  19. [19]
    J. A. Shipley, H. F. Pompe van Meerdervoort and J. van den Ende,Gentamicin-polymethyl-methacrylate beads in the treatment of chronic bone sepsis. S. Afr. Med. J.59, 905–907 (1981).PubMedGoogle Scholar
  20. [20]
    S.-A. Hedstrom, L. Lidgren, C. Torholm and R. Onnerfalt,Antibiotic containing bone cement beads in the treatment of deep muscle and skeletal infections. Acta Orthop. Scand.51, 863–869 (1980).PubMedGoogle Scholar
  21. [21]
    C. H. Dohlman, D. Pavan-Langston and J. Rose,A new ocular insert device for continuous constant-rate delivery of medication to the eye. Ann. Ophthal.4, 823–832 (1972).PubMedGoogle Scholar
  22. [22]
    N. Keller, A. M. Longwell and S. A. Birss,Intermittent vs. continuous steroid administration. Arch. Ophthalmol.94, 644–652 (1976).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • S. Cawley
    • 1
  • D. J. Ormrod
    • 1
  • J. W. Paxton
    • 2
  • T. E. Miller
    • 1
  1. 1.Department of MedicineAuckland HospitalAucklandNew Zealand
  2. 2.Department of Pharmacology, School of MedicineUniversity of AucklandAucklandNew Zealand

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