Sustained release of a corticosteroid using polymeric implants
- 24 Downloads
An effective sustained release method of drug administration, using methylprednisolone incorporated into acrylic bone cement, has been developed. The effect of this form of treatment on peripheral blood leukocytes, lymphoid tissue weight and the inflammatory response has been evaluated. This mode of methylprednisolone administration was compared with conventional systemic therapy and was found to produce rapid and prolonged pharmacological effects at very low plasma levels of drug. A dose response relationship was established and we determined that, for a given quantity of drug, the level and duration of suppression was greater using sustained release therapy. The inflammatory response was also depressed using this mode of administration. These results, coupled with the commercial availability and existing clinical approval of SIMPLEX P bone cement, suggest that further development may lead to useful clinical protocols.
KeywordsMethylprednisolone Systemic Therapy Lymphoid Tissue Sustained Release Response Relationship
Abbreviations used in this paper
Unable to display preview. Download preview PDF.
- J. R. Salaman,Steroids and modern immunosuppression. Brit. Med. J.286, 1373–1375 (1983).Google Scholar
- C. Ponticelli, A. F. De Vecchi, A. Tarantino, E. Rivolta, F. M. Egidi, L. Berardinelli and A. Vegeto,A search for optimizing corticosteroid administration to renal transplant patients. Kidney Int.23, S85-S89 (1983).Google Scholar
- R. C. Haynes and F. Murad, Adrenocorticotropic hormone; Adrenocortical Steroids and their synthetic analogs; inhibitors of Adrenocortical steroid biosynthesis. InThe Pharmacological Basis of Therapeutics, pp. 1466–1496 (Eds. A. G. Gilman, L. S. Goodman and A. Gilman). Mac-Millan Publishing Co., New York 1980.Google Scholar
- S. K. Chandrasekaran, H. Benson and J. Urquhart, Methods to achieve controlled drug delivery — The biomedical engineering approach. InSustained and Controlled Release Drug Delivery Systems, pp. 557–594 (Ed. J. Robinson). Marcel Dekker, New York 1978.Google Scholar
- D. R. Cowsar, O. R. Tarwater and A. C. Tanquary, Controlled release of fluoride from hydrogels for dental applications. InHydrogels for Medical and Related Applications, pp. 180–197 (Ed. J. D. Andrade). ACS, Washington 1976.Google Scholar
- T. E. Miller and D. Ormrod,The anti-inflammatory activity of Perna canaliculus (NZ green lipped mussel). NZ Med. J.92, 187–193 (1980).Google Scholar
- K. R. Sidman, A. D. Schwope, W. D. Steber, S. E. Rudolph and S. B. Poulin,Use of synthetic polypeptides for biodegradable drug delivery systems. Polymer Preprints20, 27 (1979).Google Scholar
- Y. W. Chien,Novel drug delivery systems. Marcel Dekker, New York 1982.Google Scholar
- L. R. Beck and T. R. Tice, Poly(lactic acid) and poly(lactic acid-co-glycolic acid) contraceptive delivery systems. InLong-Acting Steroidal Contraception, pp. 175–188 (Ed. D. R. Mishell). Raven Press, New York 1983.Google Scholar