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, Volume 19, Issue 3–4, pp 233–243 | Cite as

Sustained release of a corticosteroid using polymeric implants

  • S. Cawley
  • D. J. Ormrod
  • J. W. Paxton
  • T. E. Miller
Immunosuppression and Inflammation

Abstract

An effective sustained release method of drug administration, using methylprednisolone incorporated into acrylic bone cement, has been developed. The effect of this form of treatment on peripheral blood leukocytes, lymphoid tissue weight and the inflammatory response has been evaluated. This mode of methylprednisolone administration was compared with conventional systemic therapy and was found to produce rapid and prolonged pharmacological effects at very low plasma levels of drug. A dose response relationship was established and we determined that, for a given quantity of drug, the level and duration of suppression was greater using sustained release therapy. The inflammatory response was also depressed using this mode of administration. These results, coupled with the commercial availability and existing clinical approval of SIMPLEX P bone cement, suggest that further development may lead to useful clinical protocols.

Keywords

Methylprednisolone Systemic Therapy Lymphoid Tissue Sustained Release Response Relationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this paper

BC

bone cement

MP

methylprednisolone

PMN

polymorphonuclear leukocyte

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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • S. Cawley
    • 1
  • D. J. Ormrod
    • 1
  • J. W. Paxton
    • 2
  • T. E. Miller
    • 1
  1. 1.Department of MedicineAuckland HospitalAucklandNew Zealand
  2. 2.Department of Pharmacology, School of MedicineUniversity of AucklandAucklandNew Zealand

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