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3H-Tiotidine binding to guinea-pig cortical and striatal membranes

Agents and Actions volume 19, pages 169–173 (1986)Cite this article

Abstract

3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor (ref. 6). We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable3H-tiotidine binding was observed also in the nucleus accumbens.

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  1. Smith Kline & French Research Limited, The Frythe, AL6 9AR, Welwyn, Hertfordshire, England

    I. R. Smith, B. K. Leigh & M. E. Mylek

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  1. I. R. Smith
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  2. B. K. Leigh
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Smith, I.R., Leigh, B.K. & Mylek, M.E. 3H-Tiotidine binding to guinea-pig cortical and striatal membranes. Agents and Actions 19, 169–173 (1986). https://doi.org/10.1007/BF01966202

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  • DOI: https://doi.org/10.1007/BF01966202

Keywords

  • Nucleus Accumbens
  • Striatal Membrane
  • Affinity Relationship
  • Affinity Study
  • Suitable Radioligand