Experientia

, Volume 41, Issue 4, pp 498–500 | Cite as

Effect of aminoglutethimide on murine fetal hepatic erythroid colony formation

  • P. Leung
  • A. S. Gidari
Short Communications

Summary

Pretreatment of pregnant mice with aminoglutethimide phosphate, an inhibitor of glucocorticoid synthesis, increases the content of fetal liver erythroid colony-forming cells (CFU-E), as assessed by the formation of erythroid colonies in vitro by fetal liver cells in plasma clots containing exogenous erythropoietin. In addition, the inability of aminoglutethimide to influence erythroid colony formation in vitro suggests that endogenous glucocorticoids exert a suppressive effect on the number of functional CFU-E in the fetal liver.

Key words

Mice pregnant aminoglutethimide phosphate mice liver fetal erythroid colony-forming cells 

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References

  1. 3.
    Agius, C., and Gidari, A. S., J. Lab. clin. Med.100, (1982) 178.PubMedGoogle Scholar
  2. 4.
    Baxter, J. D., and Tomkins, G. M., Proc. natn. Acad. Sci. USA68 (1971) 932.Google Scholar
  3. 5.
    Bearn, J. G., Acta Anat.68 (1967) 239.PubMedGoogle Scholar
  4. 6.
    Billat, C. L., Felix, J. M., and Jacquot, R. L., Exp. Hemat.10 (1982) 133.PubMedGoogle Scholar
  5. 7.
    Billat, C., Felix, J. M., Mayeux, P., and Jacquot, R., J. Endocr.89 (1981) 307.PubMedGoogle Scholar
  6. 8.
    Chung, K. W., Pharmacologist24 (1982) 215 (abstr.).Google Scholar
  7. 9.
    Dunn, C. D. R., and Napier, J. A. F., Exp. Hemat.4 (1976) 289.PubMedGoogle Scholar
  8. 10.
    Fishman, L. M., Liddle, G. W., Island, D. P., Fleischer, N., and Kuchel, O., J. clin. Endocr. Metab.27 (1967) 481.PubMedGoogle Scholar
  9. 11.
    Gidari, A. S., J. Cell Physiol.109 (1981) 419.CrossRefPubMedGoogle Scholar
  10. 12.
    Gidari, A. S., and Levere, R. D., J. Lab. clin. Med.98 (1979) 872.Google Scholar
  11. 13.
    Golde, D. W., Bersch, N., and Cline, M. J., J. clin. Invest.57 (1976) 57.PubMedGoogle Scholar
  12. 14.
    Goldman, A. S., Endocrinology86 (1970) 1245.PubMedGoogle Scholar
  13. 15.
    Graves, P. E., and Salhanick, H. A., Endocrinology105 (1979) 52.PubMedGoogle Scholar
  14. 16.
    Gregory, C. J., J. Cell Physiol.89 (1976) 289.CrossRefPubMedGoogle Scholar
  15. 17.
    Hackney, J. F., Gross, S. R., Aronow, L.,and Pratt, W. B., Molec. Pharmac.6 (1970) 500.Google Scholar
  16. 18.
    Hassan, M. W., Ibrahim, A., and Rieder, R. F., Proc. Soc. exp. Biol. Med.169 (1982) 63.PubMedGoogle Scholar
  17. 19.
    Heath, D. S., Axelrad, A. A., McLeod, D. L., and Shreeve, M. M., Blood47 (1976) 777.PubMedGoogle Scholar
  18. 20.
    Leung, P., Diss., State University of New York, Downstate Medical Center, University Microfilms International. Ann Arbor, MI, 1983.Google Scholar
  19. 21.
    Leung, P., and Gidari, A. S., Endocrinology108, (1981) 1787.PubMedGoogle Scholar
  20. 22.
    Leung, P., and Gidari, A. S., Blood60 (suppl. 1) (1982) 279.PubMedGoogle Scholar
  21. 23.
    Liggins, G. C., and Kennedy, P. C., J. Endocr.40 (1968) 371.PubMedGoogle Scholar
  22. 24.
    Mayeux, P., Billat, C., Felix, J. M., and Jacquot, R., J. Endocr.96 (1983) 311.PubMedGoogle Scholar
  23. 25.
    McLeod, D. L., Shreeve, M. M., and Axelrad, A. A., Blood44 (1974) 517.PubMedGoogle Scholar
  24. 26.
    Nagel, J., and Jacquot, R., Arch. Anat. microsc. Morph. exp.57 (1968) 99.Google Scholar
  25. 27.
    Nagel, J., and Jacquot, R., Arch. Anat. Microsc. Morph. exp.,58 (1969) 97.Google Scholar
  26. 28.
    Peschle, C., Magli, M. C., Cillo, C., Lettieri, F., Pizzella, F., Migliaccia, G., and Sasso, G. F., in: In Vitro Aspects of Erythropoiesis, p. 86. Eds M. J. Murphy, C. Peschle, A. S. Gordon and E. A. Mirand, Springer-Verlag, New York 1978.Google Scholar
  27. 29.
    Rifkind, R. A., Chui, D., and Epler, H. J. Cell. Physiol.40 (1969) 343.Google Scholar
  28. 30.
    Roodman, G. D., Lee, J., and Gidari, A. S., Br. J. Haemat.53 (1983) 621.Google Scholar
  29. 31.
    Schooley, J. C., Garcia, J. F., Cantor, L. N., and Haven, V. W., Ann. N.Y. Acad. Sci.149 (1968) 266.PubMedGoogle Scholar
  30. 32.
    Singer, J. W., Samuels, A. I., and Adamson, J. W., J. Cell Physiol.88 (1976) 127.CrossRefPubMedGoogle Scholar
  31. 33.
    Snedecor, G. W., and Cochran, W. G., in: Statistical Methods, 6th ed., p. 100, 265, 273.Iowa State University Press Ames 1967.Google Scholar
  32. 34.
    Stephenson, J. R., Axelrad, A. A., McLeod, D. L., and Shreeve, M. M., Proc. natn. Acad. Sci. USA68 (1971) 1542.Google Scholar
  33. 35.
    Tarbutt, R. G., and Cole, R. J., J. Embryol. exp. Morph.24 (1970) 429.PubMedGoogle Scholar
  34. 36.
    Thiel, D. H. V., Estes, L. W., Richey, J. E., Little, J. M., and Graham, T. O., Endocrinology107 (1980) 557.PubMedGoogle Scholar
  35. 37.
    Thompson, A. Jr., and Siiteri, P. K., J. biol. Chem.249 (1974) 5373.PubMedGoogle Scholar
  36. 38.
    Uzgiris, V. I., Graves, P. E., and Salhanick, H. A., Biochemistry16 (1977) 593.CrossRefPubMedGoogle Scholar
  37. 39.
    Zanjani, E. D., and Banisadre, M., J. clin. Invest.64 (1979) 1181.PubMedGoogle Scholar
  38. 40.
    Zanjani, E. D., Mann, L. I., Burlington, H., Gordon, A. S., and Wasserman, L. R., Blood44 (1974) 285.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • P. Leung
    • 1
  • A. S. Gidari
    • 1
  1. 1.Department of PharmacologyState University of New York, Downstate Medical CenterBrooklynUSA

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