, Volume 41, Issue 4, pp 498–500 | Cite as

Effect of aminoglutethimide on murine fetal hepatic erythroid colony formation

  • P. Leung
  • A. S. Gidari
Short Communications


Pretreatment of pregnant mice with aminoglutethimide phosphate, an inhibitor of glucocorticoid synthesis, increases the content of fetal liver erythroid colony-forming cells (CFU-E), as assessed by the formation of erythroid colonies in vitro by fetal liver cells in plasma clots containing exogenous erythropoietin. In addition, the inability of aminoglutethimide to influence erythroid colony formation in vitro suggests that endogenous glucocorticoids exert a suppressive effect on the number of functional CFU-E in the fetal liver.

Key words

Mice pregnant aminoglutethimide phosphate mice liver fetal erythroid colony-forming cells 


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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • P. Leung
    • 1
  • A. S. Gidari
    • 1
  1. 1.Department of PharmacologyState University of New York, Downstate Medical CenterBrooklynUSA

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