, Volume 41, Issue 4, pp 488–489 | Cite as

Sympathectomy enhances the substance P-mediated breakdown of the blood-aqueous barrier in response to infrared irradiation of the rabbit iris

  • G. Bynke
  • A. Bruun
  • R. Håkanson
Short Communications


Rabbits were subjected to infrared irradiation of the iris 1 month after unilateral cervical sympathectomy. The resulting breakdown of the blood-aqueous barrier was greatly enhanced on the sympathectomized side. In contrast, the response to intravitreally injected substance P (SP) was the same in both eyes. The enhancement of the response to IR irradiation could be abolished by pretreatment with an SP antagonist, (D-Pro2, D-Trp7,9)-SP.

Key words

Rabbit iris cervical sympathectomy blood-aqueous barrier infrared irradiation substance P antagonist miosis 


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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • G. Bynke
    • 1
  • A. Bruun
    • 1
  • R. Håkanson
    • 1
  1. 1.Departments of Experimental Ophthalmology and PharmacologyUniversity of LundLund(Sweden)

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