Summary
Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.
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Faigle, J.W., Stierlin, H., Mory, H. et al. Indoxyl derivatives of drug metabolites. Experientia 41, 476–478 (1985). https://doi.org/10.1007/BF01966155
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DOI: https://doi.org/10.1007/BF01966155