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Tricyclic antidepressants antagonize prostaglandin (PG) E20induced contractions of the guinea pig ileum and hypomotility in the mouse

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Summary

The interactions of PGE2 and 2 tricyclic antidepressants were tested both on the guinea pig ileum and motility in the mouse. PGE2-induced contractions of the guinea pig ileum were irreversibly blocked by amitriptyline and desipramine. Chronic administration of amitriptyline and desipramine blocked PGE2-induced hypomotility in the mouse.

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria

    Fola M. Tayo

  2. Department of Pharmacology, University of Vermont Medical College, Given Building, 05405, Burlington, Vt, USA

    Fola M. Tayo

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  1. Fola M. Tayo
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Tayo, F.M. Tricyclic antidepressants antagonize prostaglandin (PG) E20induced contractions of the guinea pig ileum and hypomotility in the mouse. Experientia 41, 474–476 (1985). https://doi.org/10.1007/BF01966154

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  • DOI: https://doi.org/10.1007/BF01966154

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