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Cerebrovascular reactivity to CO2: Modulation by arterial pressure

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Summary

Cerebrovascular reactivity to CO2 (CO2R), measured in halothane-anesthetized rabbits, decreased as arterial pressure was increased either pharmacologically or mechanically. On the other hand, hypotension, induced by bleeding, led to an increase in CO2R. These responses were unaffected by denervation of baroreceptors.

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Authors and Affiliations

  1. Departments of Physiology and Anesthesiology and The Brain Research Institute, University of California School of Medicine, 90024, Los Angeles, California, USA

    J. D. Lifson, E. H. Rubinstein, O. U. Scremin & R. R. Sonnenschein

Authors
  1. J. D. Lifson
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  2. E. H. Rubinstein
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  3. O. U. Scremin
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  4. R. R. Sonnenschein
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Additional information

This work was supported by grants from NIH (HL 17903) and American Heart Association — Greater Los Angeles Affiliate (437IG). To whom requests for reprints should be sent.

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Lifson, J.D., Rubinstein, E.H., Scremin, O.U. et al. Cerebrovascular reactivity to CO2: Modulation by arterial pressure. Experientia 41, 467–468 (1985). https://doi.org/10.1007/BF01966150

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  • DOI: https://doi.org/10.1007/BF01966150

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