Experientia

, Volume 36, Issue 9, pp 1127–1128 | Cite as

Plasma cyclic 3′,5′-guanosine monophosphate and cyclic 3′,5′-adenosine monophosphate response to methacholine in man

  • S. Hata
  • F. Okada
  • M. Honma
  • M. Ui
Specialia

Summary

Cholinergic agents are known to induce increases in tissue and plasma levels of cyclic GMP in experimental animals. We observed that i.m. injection of methacholine, a cholinergic agent, caused significant increases in plasma cyclic GMP and cyclic AMP in man.

Keywords

Adenosine Experimental Animal Plasma Level Monophosphate Guanosine 

References

  1. 1.
    W. J. George, J. B. Polson, A. G. O'Toole and N. D. Goldberg, Proc. natl. Acad. Sci. USA66, 398 (1970).PubMedGoogle Scholar
  2. 2.
    T. P. Lee, J. F. Kuo and P. Greengard,Proc. natl. Acad. Sci. USA69, 3287 (1972).PubMedGoogle Scholar
  3. 3.
    J. P. Christopher, E. K. Frandsen, T. P. Conlon, G. Kishna and J. D. Gardner, J. biol. Chem.251, 4640 (1970).Google Scholar
  4. 4.
    J. H. Eichhorn, E. W. Salzman and W. Silen, Nature248, 238 (1974).PubMedGoogle Scholar
  5. 5.
    M. Honma and M. Ui, Eur. J. Pharmac.47, 1 (1978).Google Scholar
  6. 6.
    M. Honma, T. Satoh, J. Takezawa and M. Ui, Biochem. Med.18, 257 (1977).PubMedGoogle Scholar
  7. 7.
    A. L. Steiner, C. W. Parker and D. M. Kipnis, J. biol. Chem.247, 1106 (1972).PubMedGoogle Scholar
  8. 8.
    J. H. Ball, N. I. Kaminsky, J. G. Hardman, A. E. Broadus, E. W. Sutherland and G. W. Liddle, J. clin. Invest.51, 2124 (1972).PubMedGoogle Scholar
  9. 9.
    S. A. Leveston, S. D. Shah and P. E. Cryer. J. clin. Invest.64, 374 (1979).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • S. Hata
    • 1
  • F. Okada
    • 1
  • M. Honma
    • 1
  • M. Ui
    • 1
  1. 1.The Second Department of Internal Medicine, School of Medicine, Department of Psychiatry and Neurology, and Physiological Chemistry, Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

Personalised recommendations