Experientia

, Volume 36, Issue 9, pp 1098–1099 | Cite as

Radiation-induced changes in gentamicin pharmacokinetics

  • T. Trnovec
  • Š. Bezek
  • J. Navarová
  • M. Gregušková
  • M. Kettner
  • V. Laginová
Specialia

Summary

Decreased clearance of i.v. or intratracheally administered gentamicin was observed in rats following single whole-body irradiation, 6 Gy60Co, reaching its lowest rate on the 7th post-irradiation day. Simultaneously the absorption rate of gentamicin from the lungs was found to be increased.

Keywords

Gentamicin Absorption Rate Gentamicin Pharmacokinetic 

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • T. Trnovec
    • 1
  • Š. Bezek
    • 1
  • J. Navarová
    • 1
  • M. Gregušková
    • 1
  • M. Kettner
    • 1
  • V. Laginová
    • 1
  1. 1.Institute of Experimental Pharmacology, Centre of Physiological SciencesSlovak Academy of SciencesBratislava(Czechoslovakia)

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