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In vivo3H-d-LSD binding in small punched out rat brain regions

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Summary

We have developed an in vivo3H-d-LSD-binding method in the rat brain to measure the3H-d-LSD concentration in specific brain regions and nuclei. In the cortex, d-LSD binding sites increase from the occipital to the frontal part without a change in their affinity. Compared to the hippocampus, striatum, cortex and raphe nuclei, the substantia nigra contains a d-LSD binding site of lower affinity.

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References

  1. K. Kräuchi, H. Feer, M. Lichtsteiner and A. Wirz-Justice, Experientia34, 761 (1978).

    Article  PubMed  Google Scholar 

  2. G. R. Christoph, D. M. Kuhn and B. L. Jacobs, Life Sci.21, 1585 (1977).

    Article  CAS  PubMed  Google Scholar 

  3. H. J. Haigler and G. K. Aghajanian Fed. Proc.36, 2159 (1977).

    CAS  PubMed  Google Scholar 

  4. J. E. Leysen, C. J. E. Niemegeers, J. P. Tollenaere and P. M. Laduron, Nature272, 168 (1978).

    Article  CAS  PubMed  Google Scholar 

  5. L. Pieri, M. Pieri and W. Haefely, Nature252, 586 (1974).

    Article  CAS  PubMed  Google Scholar 

  6. J. F. R. König and R. A. Klippel, The rat brain. A stereotaxic atlas. Krieger, Huntington, NY, 1970.

    Google Scholar 

  7. J. P. Bennet and S. H. Snyder, Brain Res.94, 523 (1975).

    Article  Google Scholar 

  8. P. M. Laduron, P. F. M. Janssen and J. E. Leysen, Biochem. Pharmac.27, 317 (1978).

    Article  CAS  Google Scholar 

  9. S. J. Peroutka and S. H. Snyder, Molec. Pharmac.16, 687 (1979).

    CAS  Google Scholar 

  10. J. W. Kebabian and D. B. Calne, Nature277, 93 (1979).

    Article  CAS  PubMed  Google Scholar 

  11. J. Premont, A. M. Thierry, J. P. Tassin, J. Glowinski, G. Blanc and J. Bockaert, FEBS Lett.68, 99 (1976).

    Article  CAS  PubMed  Google Scholar 

  12. H. Y. Meltzer, R. G. Fessler, M. Simonovic, J. Doherty and V. S. Fang, Psychopharmacology54, 99 (1977).

    Google Scholar 

  13. M. E. Trulson, C. A. Ross and B. L. Jacobs, Neuropharmacology16, 771 (1977).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Psychiatrische Universitätsklinik, Wilhelm-Klein-Strasse 27, CH-4025, Basel, Switzerland

    K. Kräuchi & H. Feer

Authors
  1. K. Kräuchi
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  2. H. Feer
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Additional information

Acknowledgment. We thank M. Lichtsteiner for skillful technical assistence, and Dr. C. Gentsch for helpful discussion of the manuscript.

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Kräuchi, K., Feer, H. In vivo3H-d-LSD binding in small punched out rat brain regions. Experientia 36, 1094–1095 (1980). https://doi.org/10.1007/BF01965989

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