, Volume 36, Issue 9, pp 1080–1082 | Cite as

Evidence that endogenous vasopressin plays a protective role in circulatory shock. Role for reticuloendothelial system using Brattleboro rats

  • B. M. Altura


Experiments performed on male Wistar, Long Evans and Brattleboro rats indicate that the latter strain of animals, lacking vasopressin in their posterior pituitaries, are extremely sensitive to hemorrhagic and bowel ischemic shock. Mild forms of both hemorrhagic and bowel ischemic shock, as produced in Wistar on Long Evans rats, results in marked hypotension, hemoconcentration and blockade of the reticuloendothelial system (RES) in Brattleboro animals of similar sex, age and weight. These direct findings indicate that release of endogenous vasopressin in shock syndromes may be critical in maintenance of circulatory homeostasis and RES function.


Vasopressin Protective Role Direct Finding Mild Form Reticuloendothelial System 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • B. M. Altura
    • 1
  1. 1.Downstate Medical Center, Department of PhysiologyState University of New YorkBrooklynUSA

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