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Effects of thyrotrophic-releasing hormone (TRH) on thermoregulation in the rat

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Summary

At ambient temperatures (Ta) of both 8 and 22°C, intraventricular administration of TRH (10–80 μg) produced a dose-dependent hypothermia in rats. The hypothermia was due to both decreased metabolic heat production and cutaneous vasodilatation. In contrast, at 30°C Ta, TRH increased metabolic heat production (due to behavioral excitation) and led to hyperthermia.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan

    M. T. Lin, A. Chandra, Y. F. Chern & B. L. Tsay

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  1. M. T. Lin
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  2. A. Chandra
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  3. Y. F. Chern
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  4. B. L. Tsay
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Additional information

This work was supported by the grants from the National Science Council of Republic of China and the Pjing-Ling Neurological Foundation (VGH, Taipei, Taiwan).

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Lin, M.T., Chandra, A., Chern, Y.F. et al. Effects of thyrotrophic-releasing hormone (TRH) on thermoregulation in the rat. Experientia 36, 1077–1078 (1980). https://doi.org/10.1007/BF01965979

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  • DOI: https://doi.org/10.1007/BF01965979

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