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Binding of antimalarial drugs to hemozoin fromPlasmodium berghei

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Summary

Chloroquine, quinacrine and mefloquine bind toPlasmodium berghei hemozoin, hemin, heme, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, 4, Bangkok, Thailand

    A. Jearnpipatkul, P. Govitrapong, Y. Yuthavong, P. Wilairat & B. Panijpan

Authors
  1. A. Jearnpipatkul
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  2. P. Govitrapong
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  3. Y. Yuthavong
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  4. P. Wilairat
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  5. B. Panijpan
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Additional information

Acknowledgments. We thank the World Health Organization, the National Research Council of Thailand and Mahidol University for financial support. Dr Prapin Wilairat's suggestions are appreciated.

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Jearnpipatkul, A., Govitrapong, P., Yuthavong, Y. et al. Binding of antimalarial drugs to hemozoin fromPlasmodium berghei. Experientia 36, 1063–1064 (1980). https://doi.org/10.1007/BF01965970

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  • DOI: https://doi.org/10.1007/BF01965970

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