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, Volume 12, Issue 4, pp 499–502 | Cite as

The effect of protease inhibitors on the immune response in mice

  • Pierre Descombes
  • Jean-Pierre Olivier
  • Thomas L. Vischer
Immunosuppression and Inflammation


The effect of protease inhibitors on the immune response in mice was investigated. Soybean inhibitor, aprotinin, α-antitrypsin and ovomucoid (1 mg) diminished significantly the direct plaque forming cell response per spleen 3 days after immunization with 108 sheep erythrocytes (SRBC), when given at the same time as the antigen. With α-antitrypsin, the effect was not significant 4 days after immunization. With soybean inhibitor, no significant suppressive effect was seen, when the inhibitor was given either 24 hours before or after the antigen. Both aprotinin and ovomucoid diminished a secondary response to SRBC, limited to the indirect plaque forming cells. Soybean inhibitor had an equivocal effect on the secondary response. A suppressive effect of soybean inhibitor, but not ovomucoid was seen using KLH-FITC or LPS-FITC as antigens. Neither soybean inhibitor nor aprotinin, had an effect on the induction of delayed-type skin reactivity to, oxazolone or FITC.


Immune Response Protease Inhibitor Cell Response FITC Suppressive Effect 


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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • Pierre Descombes
    • 1
  • Jean-Pierre Olivier
    • 1
  • Thomas L. Vischer
    • 1
  1. 1.Division of Rheumatology, University Department of MedicineHôpital Beau-SéjourGeneva 4Switzerland

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