Skip to main content
SpringerLink
Log in

Distribution and pharmacokinetics of14C-toxiferine in rats

  • Research Reports
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The distribution of14C-toxiferine in rats was investigated using a combustion method in combination with whole-body autoradiograms at different time intervals after intravenous injection. The distribution is essentially the same as those of other non-depolarizing curare drugs. In contrast to the short-acting N-N′-diallyl-bis-nor-toxiferine (Alcuronium) only minor periodic shifts within the different compartments of the organism, little binding to mucopolysaccharides in connective tissue and cartilage and slow elimination were found. This may explain the long paralytic action of toxiferine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. N. Cohen, A. Corbascio andG. Fleischli,The Distribution and Fate of d-Tubocurarine J. Pharmac. exp. Ther.147, 120–129 (1965).

    Google Scholar 

  2. E. N. Cohen, H. W. Brewer andD. Smith,The Metabolism and Elimination of d-Tubocurarine-H 3, Anesthesiology28, 309–317 (1967).

    PubMed  Google Scholar 

  3. F. Kalberer,A New Method of Macroautoradiography, Advances in Tracer Methodology, vol. 3 (Plenum Press, New York 1960), p. 139–147.

    Google Scholar 

  4. F. Kalberer andJ. Rutschmann,Eine Schnellmethode zur Bestimmung von Tritium, Radiokohlenstoff und Radioschwefel in beliebigem organischem Probenmaterial mittels des Flüssigkeits-Scintillationszählers, Helv. chim. Acta44, 1956–1966 (1961).

    Article  Google Scholar 

  5. U. Lüthi,Verteilung und Metabolismus von curarisierenden Substanzen, Bull. schweiz. Akad. med. Wiss.22, 501–510 (1966).

    Google Scholar 

  6. U. Lüthi andP. G. Waser,Verteilung und Metabolismus von 14 C-Carbachol bei atropinisierten Katzen. Arch. int. Pharmacodyn.,167, 369–402 (1967).

    PubMed  Google Scholar 

  7. P. G. Waser,Autoradiographic Studies of Motor Endplates with toxiferine, in:Preparation and Biomedical Application of Labelled Molecules (publ. by Euratom 2200e, Brussels 1964), p. 365–371.

    Google Scholar 

  8. P. Waser, H. Schmid andK. Schmid,Resorption, Verteilung und Ausscheidung von Radio-Calebassen-Curarin bei Katzen, Arch. int. Pharmacodyn.96, 386–405 (1954).

    PubMed  Google Scholar 

  9. P. G. Waser andU. Lüthi,Verteilung, Metabolismus und Elimination von 3 H-Diallylnor-Toxiferin (Alloferin) bei Katzen, Helv. physiol. Acta24, 259–273 (1966).

    Google Scholar 

  10. O. Wassermann,Studies on the Pharmacokinetics of Bis-Quaternary Ammonium Compounds; II. Autoradiographic Studies on the Distribution of 3 H-Hexamethonium in Mice, Naunyn-Schmiedebergs Arch. Pharmak.270, 419–427 (1971).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Zürich, Zürich, Schweiz

    P. G. Waser & J. Reller

Authors
  1. P. G. Waser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Reller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waser, P.G., Reller, J. Distribution and pharmacokinetics of14C-toxiferine in rats. Agents and Actions 2, 170–175 (1972). https://doi.org/10.1007/BF01965855

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01965855

Keywords

Search

Navigation