Distribution and pharmacokinetics of14C-toxiferine in rats
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The distribution of14C-toxiferine in rats was investigated using a combustion method in combination with whole-body autoradiograms at different time intervals after intravenous injection. The distribution is essentially the same as those of other non-depolarizing curare drugs. In contrast to the short-acting N-N′-diallyl-bis-nor-toxiferine (Alcuronium) only minor periodic shifts within the different compartments of the organism, little binding to mucopolysaccharides in connective tissue and cartilage and slow elimination were found. This may explain the long paralytic action of toxiferine.
KeywordsConnective Tissue Intravenous Injection Mucopolysaccharide Curare Drug Slow Elimination
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- E. N. Cohen, A. Corbascio andG. Fleischli,The Distribution and Fate of d-Tubocurarine J. Pharmac. exp. Ther.147, 120–129 (1965).Google Scholar
- F. Kalberer,A New Method of Macroautoradiography, Advances in Tracer Methodology, vol. 3 (Plenum Press, New York 1960), p. 139–147.Google Scholar
- U. Lüthi,Verteilung und Metabolismus von curarisierenden Substanzen, Bull. schweiz. Akad. med. Wiss.22, 501–510 (1966).Google Scholar
- P. G. Waser,Autoradiographic Studies of Motor Endplates with toxiferine, in:Preparation and Biomedical Application of Labelled Molecules (publ. by Euratom 2200e, Brussels 1964), p. 365–371.Google Scholar
- P. G. Waser andU. Lüthi,Verteilung, Metabolismus und Elimination von 3 H-Diallylnor-Toxiferin (Alloferin) bei Katzen, Helv. physiol. Acta24, 259–273 (1966).Google Scholar