Alfalfa seeds: Effects on cholesterol metabolism


Plasma cholesterol concentrations were reduced in 3 human volunteers during ingestion of diets containing alfalfa seeds (AS) for 3 weeks. No signs of toxicity were detected through serum determinations of multiple parameters. The ingestion of AS in rats decreased the concentration of plasma cholesterol, reduced intestinal absorption of exogenous and endogenous cholesterol, and increased fecal biliary excretion.

This is a preview of subscription content, log in to check access.


  1. 2

    F. B. Cookson, R. Altschul and S. Federoff, J. Atheroscler. Res.7, 69 (1967).

    PubMed  Google Scholar 

  2. 3

    M. R. Malinow, P. McLaughlin, H. K. Naito, L. A. Lewis and W. P. McNulty, Atherosclerosis30, 27 (1978).

    Article  PubMed  Google Scholar 

  3. 4

    M. R. Malinow, 60th Annual Meeting, Pacific Division, American Association for Advancement of Science, University of Idaho, Moscow, 3–7 June 1979, p. 30.

  4. 5

    Atlas of Nutritional Data on U.S. and Canadian Feeds p. 44. Natl Acad. Sci., Washington, D.C., 1972.

  5. 6

    L. L. Rudel and M. D. Morris, J. Lipid Res.14, 364 (1973).

    PubMed  Google Scholar 

  6. 7

    M. Burstein, H. R. Scholnick and R. Morfin, J. Lipid Res.11, 583 (1970).

    PubMed  Google Scholar 

  7. 8

    M. R. Malinow, P. McLaughlin, L. Papworth, C. Stafford, G. O. Kohler, A. L. Livingston and P. R. Cheeke, Am. J. clin. Nutr.30, 2061 (1977).

    PubMed  Google Scholar 

  8. 9

    J. L. Bollman and E. Van Hook, J. appl. Physiol.24, 722 (1968).

    PubMed  Google Scholar 

  9. 10

    M. R. Malinow and P. McLaughlin, Atherosclerosis15, 153 (1972).

    PubMed  Google Scholar 

  10. 11

    M. R. Malinow, P. McLaughlin, C. Stafford, A. L. Livingston, G. O. Kohler and P. R. Cheeke, Am. J. clin. Nutr.32, 1810 (1979).

    PubMed  Google Scholar 

  11. 12

    D. Kritchevsky and J. A. Story, Am. J. clin. Nutr.28, 305 (1975).

    PubMed  Google Scholar 

Download references

Author information



Additional information

The work described in this article, Publication No. 1082 of the Oregon Regional Primate Research Center, was supported with grants RR-00163 and HL-16587 from the National Institutes of Health.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Malinow, M.R., McLaughlin, P. & Stafford, C. Alfalfa seeds: Effects on cholesterol metabolism. Experientia 36, 562–564 (1980).

Download citation


  • Cholesterol
  • Toxicity
  • Cholesterol Concentration
  • Intestinal Absorption
  • Plasma Cholesterol