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Experientia

, Volume 36, Issue 5, pp 518–518 | Cite as

Inhibition of sterol biosynthesis by 14α-hydrocy-Δ7-sterols1

  • G. J. SchroepferJr
  • R. A. PascalJr
  • A. A. Kandutsch
Specialia

Summary

5α-Cholest-7-en-3β, 14α-diol and 5α-cholest-7-en-14α-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.

Keywords

Potent Inhibitor Reductase Activity Sterol Biosynthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • G. J. SchroepferJr
    • 1
    • 2
  • R. A. PascalJr
    • 1
    • 2
  • A. A. Kandutsch
    • 1
    • 2
  1. 1.Departments of Biochemistry and ChemistryRice UniversityHoustonUSA
  2. 2.Jackson LaboratoryBar HarborUSA

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