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, Volume 20, Issue 1–2, pp 93–97 | Cite as

The inhibition by morphine andd-aspartic acid of antibody production against Salmonella typhimurium antigen in rats: its antagonism byl-aspartic acid

  • H. Koyuncouĝlu
  • Ö Anĝ
  • D. Inanç
  • H. Saĝduyu
  • M. Güngör
Immunosuppression and Inflammation


The changes in the production of antibody against Salmonella typhimurium antigen were investigated in rats by means of the agglutination test after chronic oral administration of the,l-asparaginase inhibitors morphine (M) ord-aspartic acid (d-Asp) alone or together withl-aspartic acid (l-Asp) and food restriction, all of which had been started five days before the injections of antigen. The statistical evaluation, carried out after the titers had been defined as-log2 of the highest dilution giving a positive agglutination reaction, showed that M ord-Asp significantly decreased antibody production in comparison with the immunized control or food restricted group. The concomitant administration ofl-Asp appeared to significantly antagonize the inhibitory effect of both M andd-Asp. Therefore, the results were considered as further supporting evidence for the fact that the deleterious effect of M on the immune system and its functions might be related to the inhibitory effect of M onl-asparaginase activity.


Immune System Morphine Oral Administration Deleterious Effect Statistical Evaluation 
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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • H. Koyuncouĝlu
    • 1
  • Ö Anĝ
    • 2
  • D. Inanç
    • 3
  • H. Saĝduyu
    • 1
  • M. Güngör
    • 1
  1. 1.Dept. of Pharmacology/Istanbul Medical FacultyCapa/IstanbulTurkey
  2. 2.Dept. of Microbiology/Istanbul Medical FacultyCapa/IstanbulTurkey
  3. 3.Dept. of Microbiology/Faculty of DentistryCapa/IstanbulTurkey

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