Abstract
It seems that the gastric antral mucosa either in normal, physiological circumstances, or in IND or STR induced gastric ulcer models, contains significantly more endogenous PG-I2 than that of gastric fundic, mucosa, while the duodenal mucosa contains significantly lower endogenous PG-I2-level compared to the gastric antral or fundic level.
Either in gastric or in duodenal ulceration, the endogenous PG-I2 level basically decreased proportionally to the degree of ulceration—therefore it is tempting to speculate that the endogenous PG-I2 is most probably one of thenatural protective substances in the gastrointestinal mucosa.
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Balint, G.A., Náfrádi, J. & Varró, V. Changes of endogenous prostacyclin-level in different experimental gastroduodenal ulcer models of rat. Agents and Actions 17, 495–497 (1986). https://doi.org/10.1007/BF01965520
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DOI: https://doi.org/10.1007/BF01965520