Agents and Actions

, Volume 12, Issue 3, pp 408–411 | Cite as

Antiulcer activities of D-penicillamine copper complexes

  • John R. J. Sorenson
  • K. Ramakrishna
  • Thomas M. Rolniak
Bioinorganic Interactions


A comparison of the antiulcer activities of the polymeric cuprous, cupric disulfide and mixed valence D-penicillamine copper complexes in the Shay rat are presented. The data support the conclusion that these complexes may be less toxic and more effective than the parent compound in the therapy of arthritic diseases and/or ulcers.


Copper Disulfide Parent Compound Copper Complex Mixed Valence 
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Copyright information

© Birkhäuser Verlag Basel 1982

Authors and Affiliations

  • John R. J. Sorenson
    • 1
    • 2
  • K. Ramakrishna
    • 1
    • 2
  • Thomas M. Rolniak
    • 1
    • 2
  1. 1.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of Pharmacology, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA

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