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The diverse biological effects of Polyinosinic·Polycytidylic acid

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References

  1. A. Isaacs andJ. Lindenmann,Virus Interference: I. The Interferon, Proc. R. Soc. Med.147, 258–267 (1957).

    Google Scholar 

  2. A. K. Field, A. A. Tytell, G. P. Lampson andM. R. Hilleman,Inducers of Interferon and Host Resistance: II. Multistranded Synthetic Polynucleotide Complexes, Proc. nat. Acad. Sci. U.S.A.58, 1004–1010 (1967).

    Google Scholar 

  3. M. R. Hilleman,Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections, Arch. int. Med.126, 109–124 (1970).

    Article  Google Scholar 

  4. C. Colby andP. H. Duesberg,Double-Stranded RNA in Vaccinia Virus Infected Cells, Nature222, 940–944 (1969).

    PubMed  Google Scholar 

  5. C. Colby andM.J. Chamberlin,The Specificity of Interferon Induction in Chick Embryo Cells by Helical RNA, Proc. nat. Acad. Sci. U.S.A.63, 160–167 (1969).

    Google Scholar 

  6. E. DeClercq andT.C. Merigan,Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides, Nature222, 1148–1152 (1969).

    PubMed  Google Scholar 

  7. J.H. Park andS. Baron,Herpetic Keratoconjunctivitis: Therapy with Synthetic Double-Stranded RNA, Science162, 811–813 (1968).

    PubMed  Google Scholar 

  8. H. Gelboin andH.B. Levy,Effect of Polyinisonic Polycytidylic Acid on DMBA Carcinogenesis, Science167, 205–207 (1970).

    PubMed  Google Scholar 

  9. H.B. Levy, L.W. Law andA.S. Rabson,Inhibition of Tumor Growth by Polyinosinic Polycytidylic Acid, Proc. nat. Acad. Sci. U.S.A.62, 357–361 (1969).

    Google Scholar 

  10. H.B. Levy,Interferon and Interferon Inducers in the Treatment of Malignancies, Arch. int. Med.126, 78–83 (1970).

    Article  Google Scholar 

  11. H. Cantor, R. Asofsky andH.B. Levy,Effect of Polyinosinic Polycytidylic Acid on Graft vs Host Reaction, J. Immun.104, 1035–1038 (1970).

    PubMed  Google Scholar 

  12. W. Braun andM. Nakano,Antibody Formation: Stimulation by Polyadenylic and Polycytidylic Acids, Science157, 819–821 (1967).

    Google Scholar 

  13. E. Mozes, G. M. Shearer, M. Sela andW. Braun,Conversion with Polynucleotides of a Genetically Controlled Low Immune Response to a High Response in Mice Immunized with a Synthetic Polypeptide Antigen, in: Symposium on Biological Effects of Polynucleotides (Eds. R.F. Beers and W. Braun; Springer-Verlag, New York), in press.

  14. W. Braun, M. Ishizuka, Y. Yajima, D. Webb andR. Winchurch,Spectrum and Mode of Action of Poly A:U in the Stimulation of Immune Responses, in: Symposium on Biological Effects of Polynucleotides (Eds. R.F. Beers and W. Braun; Springer-Verlag, New York), in press.

  15. A. G. Johnson, R. E. Cone, H. M. Friedman, I. H. Han, H. G. Johnson, J. R. Schmidtke andR. G. Stout,Stimulation of the Immune System by Homopolyribonucleotides, in: Symposium on Biological Effects of Polynucleotides (Eds. R. F. Beers and W. Braun; Springer-Verlag, New York), in press.

  16. R. C. Mellors, T. Aoki andR. J. Ruebner,Further Implications of Murine Leukemia-Like Virus in the Disorders of NZB Mice, J. exp. Med.129, 1045–1062 (1968).

    Article  Google Scholar 

  17. G. Tonietti, M. B. A. Oldstone andF. J. Dixon,The Effect of Induced Chronic Viral Infections on the Immunologic Diseases of New Zealand Mice, J. exp. Med.132, 89–109 (1970).

    Article  PubMed  Google Scholar 

  18. A. D. Steinberg, S. H. Baron andN. Talal,The Pathogenesis of Autoimmunity in New Zealand Mice. I. Induction of Anti-Nucleic Acid Antibodies by Polyinosinic·Polycytidylic Acid, Proc. nat. Acad. Sci. U.S.A.63, 1102–1107 (1969).

    Google Scholar 

  19. A. D. Steinberg, T. Pincus andN. Talal,The Pathogenesis of Autoimmunity in New Zealand Mice. III. Factors Influencing the Formation of Anti-Nucleic Acid Antibodies, Immunology20, 523–531 (1971).

    PubMed  Google Scholar 

  20. A. D. Steinberg, G. G. Daley andN. Talal,Tolerance to Polyinosinic·Polycytidylic Acid in NZB/NZW Mice, Science167, 870–871 (1970).

    PubMed  Google Scholar 

  21. B. D. Stollar andV. Stollar,Immunofluorescent Demonstration of Double-Stranded RNA in the Cytoplasm of Sindbis Virus-Infected Cells, Virology42, 276–280 (1970).

    Article  PubMed  Google Scholar 

  22. R. H. Adamson, S. Fabro, E. R. Homan, R. W. O'Gara andR. P. Zendzian,Pharmacology of Polyriboinosinic: Polyribocytidylic Acid, a New Antiviral and Antitumor Agent. Antimicrob. Ag. Chemother., p. 148–152 (1970).

  23. P. A. Young, J. J. Taylor, M. C. Yu andE. Eyerman,Morphological Changes in Chick Cerebellum Induced by Poly I·Poly C, Nature228, 1191–1192 (1970).

    PubMed  Google Scholar 

  24. M. Absher andW. R. Stinebring,Toxic Properties of a Synthetic Double-Stranded RNA, Nature223, 715–717 (1969).

    PubMed  Google Scholar 

  25. M. Harris,Interferon: Clinical Application of Molecular Biology, Science170, 1068–1070 (1970).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Immunology, Veterans Administration Hospital, 94121, San Francisco, California, USA

    Norman Talal

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  1. Norman Talal
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Talal, N. The diverse biological effects of Polyinosinic·Polycytidylic acid. Agents and Actions 2, 45–49 (1971). https://doi.org/10.1007/BF01965381

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