Abstract
The in vitro activity of DuP 721 and DuP 105, two orally active members of the oxazolidinones, was compared with that of glycopeptides and ciprofloxacin against 185 gram-positive isolates. Ninety percent ofStaphylococcus aureus isolates, including penicillin- and methicillin-resistant strains, were inhibited by DuP 721 at 1 µg/ml and by DuP 105 at 16 µg/ml; DuP 721 inhibited 90% of coagulasenegative staphylococci tested at 1 µg/ml. The MIC90 forStreptococcus faecalis was 4 µg/ml with DuP 721 and 16 µg/ml with DuP 105; DuP 721 inhibited 90% of β-hemolytic streptococci of group A at 0.5 µg/ml. Similar results on selected strains were obtained by continuously recording the optical density of cultures.
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Mini, E., Novelli, A., Mazzei, T. et al. Comparative in vitro activity of the new oxazolidinones DuP 721 and DuP 105 against Staphylococci and Streptococci. Eur. J. Clin. Microbiol. Infect. Dis. 8, 256–260 (1989). https://doi.org/10.1007/BF01965273
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DOI: https://doi.org/10.1007/BF01965273