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, Volume 4, Issue 4, pp 277–285 | Cite as

Comparison of the immune response to sheep erythrocytes, tetanus toxoid and endotoxin in different strains of mice

  • J. F. Borel
Research Reports

Abstract

The primary immune response in 7 inbred and 2 outbred mouse strains to SRBC, tetanus toxin and ‘E.coli’ endotoxin is compared. Significant variations are found in the different strains concerning their antibody response to these antigens. The differences in antibody production reached with SRBC (direct and indirect PFC) and tetanus toxin are on a quantitative level, those with endotoxin also on a qualitative level. The kinetic studies further indicate that course of antibody formation as well as peak of response may considerably vary between different strains.

Keywords

Immune Response Significant Variation Antibody Response Kinetic Study Mouse Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    B. Andersson andH. Blomgren,Evidence for Thymus-Independent Humoral Antibody Production in Mice against Polyvinylpyrrolidone and E. coli Lipopolysaccharide, Cell. Immun.2, 411 (1971).CrossRefGoogle Scholar
  2. [2]
    W.F. Barth, C.L. McLaughlin andJ.L. Fahey,The Immunoglobulins of Mice. VI. Response to Immunization, J. Immun.95, 781 (1965).PubMedGoogle Scholar
  3. [3]
    R. Blackstock andR. M. Hyde,Comparison of the Ease of Tolerance Induction in Thymus and Bone Marrow of Three Strains of Mice, Cell. Immun.9, 67 (1973).CrossRefGoogle Scholar
  4. [4]
    B. Blomberg, W. R. Geckeler andM. Weigert,Genetics of the Antibody Response to Dextran in Mice, Scien177, 178 (1972).PubMedGoogle Scholar
  5. [5]
    H. C. Braley andM. J.Freeman,Strain Differences in the Antibody Plaque-Forming Cell Response of Inbred Mice to Pneumococcal Polysaccharide, Cell. Immun.2, 73 (1971).CrossRefGoogle Scholar
  6. [6]
    J. Cerny, R. F. McAlack, M. A. Sajid andH. Friedman,Genetic Differences in the Immunocyte Response of Mice to Separate Determinants on one Bacterial Antigen, Nature, New Biol.230, 247 (1971).Google Scholar
  7. [7]
    F. Dietrich,The Immune Response to Heterologous Red Cells in Mice, Immunology10, 365 (1966).PubMedGoogle Scholar
  8. [8]
    R. Di Pauli,Genetics of the Immune Response. I. Differences in the Specificity of Antibodies to Lipopolysaccharides among Different Strains of Mice, J. Immun.109, 394 (1972).PubMedGoogle Scholar
  9. [9]
    D. W. Dresser andH. H. Wortis,Localized Haemolysis in Gel, in:Handbook of Experimental Immunology, 1st ed., chap. 33 (Ed. D. M. Weir; Blackwell, Oxford-Edinburgh 1967).Google Scholar
  10. [10]
    J. L. Fahey, J. Wunderlich andR. Mishell, The Immunoglobulins of Mice. II. Two Subclasses of Mouse 7Sγ 2a- andγ-2b-Globulins, J. exp. Med.120, 243 (1964).CrossRefPubMedGoogle Scholar
  11. [11]
    A. Ghaffar andK. James,The Effect of Antilymphocytic Antibody on the Humoral Immune Response in Different Strains of Mice. II. The Response to Sheep Erythrocytes, Immunology24, 455 (1973).PubMedGoogle Scholar
  12. [12]
    E. A. Gorzynski, E. Neter andJ. L. Ambrus,Differences in Antibody Responses of Mouse Strains to Enterobacterial Common Antigen, Proc. Soc. exp. Biol. Med.134, 776 (1970).PubMedGoogle Scholar
  13. [13]
    W. M. Hale andR. D. Stoner,The Effect of Cobalt-60 Gamma Radiation on Tetanus Antitoxin Formation in Mice, J. Immunol.77, 410 (1956).PubMedGoogle Scholar
  14. [14]
    J. S. Hege andL. J. Cole,Antibody Plaque-Forming Cells: Kinetics of Primary and Secondary Responses, J. Immun.96, 559 (1966).PubMedGoogle Scholar
  15. [15]
    M. C. Holmes andF. M. Burnet,The Natural History of Autoimmune Disease in NZB Mice. A Comparison with the Pattern of Human Autoimmune Manifestations, Ann. int. Med.59, 265 (1963).PubMedGoogle Scholar
  16. [16]
    T. Imanishi andO. Mäkelä,Strain Differences in the Fine Specificity of Mouse Antihapten Antibodies, Eur. J. Immun.3, 323 (1973).Google Scholar
  17. [17]
    K. James andI. Milne,The Effect of Anti-Lymphocytic Antibody on the Humoral Immune Response in Different Strains of Mice. I. The Response to Bovine Serum Albumin, Immunology23, 897 (1972).PubMedGoogle Scholar
  18. [18]
    J. M. Jones andP. D. Kind,Enhancing Effect of Bacterial Endotoxins on Bone Marrow Cells in the Immune Response to SRBC, J. Immun.108, 1453 (1972).PubMedGoogle Scholar
  19. [19]
    E. Kölsch, E. Diller, G. Weber andA. J. S. Davils,Genetics of the Immune Response. The Immune Response to the Phage fd in High and Low Responding Inbred Strains of Mice, Eur. J. Immun.1, 201 (1971).Google Scholar
  20. [20]
    S. Levine andR. Sowinski,Experimental Allergic Encephalomyelitis in Inbred and Outbred Mice, J. Immun.110, 139 (1973).PubMedGoogle Scholar
  21. [21]
    H. O. McDevitt, B. D. Deak, D. C. Shreffier, J. Klein, J. H. Stimpfling andG. D. Snell,Genetic Control of the Immune Response. Mapping of the Ir-1 Locus, J. exp. Med.135, 1259 (1972).PubMedGoogle Scholar
  22. [22]
    J. F. A. P. Miller andG. F. Mitchell,Cell to Cell Interaction in the Immune Response. I. Hemolysin-Forming Cells in Neonatally Thymectomized Mice Reconstituted with Thymus or Thoracic Duct Lymphocytes, J. exp. Med.128, 801 (1968).CrossRefPubMedGoogle Scholar
  23. [23]
    P. H. Plotz, N. Talal andR. Asofsky,Assignment of Direct and Facilitated Hemolytic Plaques in Mice to Specific Immunoglobulin Classes, J. Immun.100, 744 (1968).PubMedGoogle Scholar
  24. [24]
    I. Riha andB. Skarova,Genetic Regulation of Antibody Response to Haptens in Inbred Strains of Mice, in:Developmental Aspects of Antibody Formation and Structure, vol. 1 (Eds J. Sterzl and I. Riha; Acad. Press, New York-London 1970), p. 235.Google Scholar
  25. [25]
    D. Sabolovic, D. Oth andC. Burg,Immunological Reactivity to Sheep Red Blood Cells in Three Congenic Resistent Strains of Mice, Immunology20, 341 (1971).PubMedGoogle Scholar
  26. [26]
    B. V. Siegel, R. E. Brooks andJ. I. Morton,Ultrastructural Aspects of Antibody Plaque-Forming Cells from Clinically Normal and Overtly Autoimmune NZB Mice, Blood35, 386 (1970).PubMedGoogle Scholar
  27. [27]
    D. M. Silver andH. J. Winn,Variations in the Responses of C57 BL and A Mice to Sheep Red Blood Cells. II. Analysis of Plaque-Forming Cells, Cell. Immun.7, 237 (1973a).Google Scholar
  28. [28]
    D. M. Silver andH. J. Winn,Use of Normal Serum to Detect Indirect Plaque-Forming Cells, J. Immun.111, 1281 (1973b).PubMedGoogle Scholar
  29. [29]
    D. M. Silver, I. F. C. McKenzie andH. J. Winn,Variations in the Responses of C57BL/10J and A/J Mice to Sheep Red Blood Cells. I. Serological Characterization and Genetic Analysis, J. exp. Med.136, 1063 (1972).CrossRefPubMedGoogle Scholar
  30. [30]
    R. D. Stoner andV. P. Bond,Antibody Formation by Transplanted Bone Marrow, Spleen, Lymph Nodes and Thymus Cells in Irradiated Recipients, J. Immun.91, 185 (1963).PubMedGoogle Scholar
  31. [31]
    G. Takatsy,The Use of Spiral Loops in Serological and Virological Micro-Methods, Acta microbiol. hung.3, 191 (1955).Google Scholar
  32. [32]
    E. M. Vaz, N. M. Vaz andB. B. Levine,Persistent Formation of Reagins in Mice Injected with Low Doses of Ovalbumin, Immunology21, 11 (1971).PubMedGoogle Scholar
  33. [33]
    B. C. Veit andJ. G. Michael,The Lack of Thymic Influence in Regulating the Immune Response to Escherichia coli 0127 Endotoxin, J. Immun.109, 547 (1972).PubMedGoogle Scholar
  34. [34]
    C. M. Warner, P. H. Maurer, C. F. Merryman andM. J. F. Schmerr,The Immune Response of Inbred Strains of Mice to a ‘High-Conjugation’ and a ‘Low-Conjugation’ 2,4-Dinitrophenylglutamic Acid-Lysine-Alanine (DNP-GLA) Copolymer, J. Immun.111, 1880 (1973).PubMedGoogle Scholar
  35. [35]
    H. H. Wortis, R. B. Taylor andD. W., Dresser,Antibody Production, Studied by Means of the LHG Assay. I. The Spleenic Response of CBA Mice to Sheep Erythrocytes, Immunology11, 603 (1966).PubMedGoogle Scholar
  36. [36]
    H. H. Wortis, D. W. Dresser andH. R. Anderson,Antibody Production Studied by Means of the Localized Haemolysis in Gel (LHG) Assay. III. Mouse Cells Producing Five Different Classes of Antibody, Immunology17, 93 (1969).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1974

Authors and Affiliations

  • J. F. Borel
    • 1
  1. 1.Biological and Medical Research DivisionSandoz Ltd.BasleSwitzerland

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