Agents and Actions

, Volume 4, Issue 4, pp 230–232 | Cite as

How aspirin might work: A pharmacokinetic approach

  • Kay Brune
Immunosuppression and Inflammation Editorials


A pharmacokinetic interpretation of the effects and side-effects of acidic non-steroid anti-inflammatory drugs is presented. It is based on the general principles of drug action and leads to the conclusion that aspirin-like drugs should specifically accumulate and exert pharmacological activity in inflammed tissue, stomach and kidney. There-fore the common effects and side-effects of these drugs may result from unspecific effects in these compartments and might not necessarily be due to specific, i.e., receptor mediated action(s).


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Copyright information

© Birkhäuser Verlag 1974

Authors and Affiliations

  • Kay Brune
    • 1
  1. 1.Dept. of PharmacologyBiocenter of the UniversityBaselSwiterland

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