, Volume 39, Issue 5, pp 527–528 | Cite as

Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes

  • E. E. Guibert
  • L. S. Morisoli
  • J. A. Monti
  • E. A. Rodriguez Garay


The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidations was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently was related to the SP dose. The results favor the conclusion that SP may inuce PNP glucuronidation in the hepatocyte.


Enzyme Enzyme Activity Protein Concentration Spironolactone Increase Enzyme Activity 


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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • E. E. Guibert
    • 1
  • L. S. Morisoli
    • 1
  • J. A. Monti
    • 1
  • E. A. Rodriguez Garay
    • 1
  1. 1.Instituto de Fisiologia Experimental, Consejo Nactional de Investigaciones Cientificas y Tecnicas (Conicet)Universidad National de RosarioRosario(Argentina)

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