, Volume 39, Issue 5, pp 514–518 | Cite as

Disruption of the goblet cell intercellular junction following histamine infusion of the rabbit ileum

  • M. Porvaznik
  • W. Baker
  • R. I. Walker


Histamine infused into the mesenteric artery of the rabbit ileum ruptured tight junctional complexes linking goblet cells with neighboring absorptive epithelial or other goblet cells. Loss of tight junctional integrity induced by histamine could contribute to extra-intestinal endotoxemia reported after a variety of injuries.


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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • M. Porvaznik
    • 1
  • W. Baker
    • 1
  • R. I. Walker
    • 1
  1. 1.Experimental Hematology DepartmentArmed Forces Radiobilogy Research InstituteBethesdaUSA
  2. 2.Histopathology DivisionNayal Dental Research InstituteGreat LakesUSA
  3. 3.Naval Medical Research InstituteBethesdaUSA

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