Agents and Actions

, Volume 12, Issue 1–2, pp 103–107 | Cite as

The effects of atropine on anaphylactic shock in the guinea-pig

  • C. Advenier
  • B. Mallard
  • M. -C. Santais
  • F. Ruff
Histamine and Kinins Histamine and Immunology

Abstract

The effects of atropine, 2 mg/kg i.v., on anaphylactic shock were studied in guinea-pigs sensitized to ovalbumin.

Atropine only moderately reduced (−31%) the increase in pulmonary resistance observed and slightly prolonged (+26%) the survival time in pretreated animals compared with controls. These effects, however, were not statistically significant. The drug temporarily improved ventilation but had no influence on haematosis.

On the other hand, atropine significantly reduced the amount of histamine released (−60%) and of GMPc synthetized in the lung (−21%). The levels of AMPc and prostaglandins E1, E2 and F remained comparable to those of control animals.

These results suggest that the reflex-induced action of the cholinergic system during anaphylaxis primarily affects large-calibre airways and that the role of acetylcholine in severe reactions is moderate when compared with the direct action of other mediators.

Keywords

Histamine Prostaglandin Survival Time Acetylcholine Control Animal 

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • C. Advenier
    • 1
    • 2
  • B. Mallard
    • 1
    • 2
  • M. -C. Santais
    • 1
    • 2
  • F. Ruff
    • 1
    • 2
  1. 1.Laboratoire de PharmacologieFaculté de Médecine Paris-Ouest, Institut biomédical des CordeliersParis Cedex 06France
  2. 2.Laboratoire de PhysiologieFaculté Necker et Laboratoire de Physiopathologie respiratoire, UER Biomédicale des Sts-PèresParis Cedex 06France

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