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, Volume 12, Issue 5, pp 662–670 | Cite as

Modulation by various locally applied anti-inflammatory and anti-allergic compounds of the immune and non-immune inflammation induced by picryl chloride in mice

  • J. P. Tarayre
  • H. Lauressergues
Immunosuppression and Inflammation

Abstract

The authors studied the primary irritation and contact delayed hypersensitivity inflammation induced by picryl chloride in mice. The primary irritation reaction was induced by the application of various concentrations of the phlogogenic agent on an ear. Seven days after contact sensitization of the animals on their shaved abdomen, the immune inflammation was also induced on an ear by various doses of picryl chloride. Clear 24 hour-delayed hypersensitivity reactions were induced only by picryl chloride doses that induced a primary oedematous irritation 3 to 6 hours after application. After selection of the 3%-concentration of picryl chloride for challenge on ear, attempts were made to modulate these two types of reaction pharmacologically with various anti-allergic or anti-inflammatory compounds mixed with the inflammation-inducing agent. The inhibition of the non-immune reaction by mepyramine, methysergide, and the two anti-allergic compounds F 1865 and disodium cromoglycate demonstrated the participation of histamine and serotonin in this inflammation. Vasoactive amines seemed also to be involved in the immune reaction, but to a lesser extent. Hydrocortisone reduced the two types of inflammation by the same amount, while desonide had more effect on the delayed hypersensitivity reaction. In addition, both indomethacin and acetylsalicylic acid affected the two reactions equally, whereas phenylbutazone had a greater effect on the primary irritation inflammation.

Keywords

Indomethacin Hypersensitivity Reaction Acetylsalicylic Acid Cromoglycate Phenylbutazone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    J.R. Frey andP. Wen,Experimental studies on the pathogenesis of contact eczema in the guinea pig, Int. Archs Allergy appl. Immun.11, 81–100 (1957).Google Scholar
  2. [2]
    G.L. Asherson andW. Ptak,Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer, Immunology15, 405–416 (1968).PubMedGoogle Scholar
  3. [3]
    G. Mouzin, H. Cousse, B. Bonnaud, J.P. Tarayre and H. Lauressergues,Anti-allergiques thiazolyl oxamates actifs par voie orale. XVII Rencontres Internationales de Chimie Thérapeutique, 9–11 septembre 1981, Besançon, Abstract book, p. 81.Google Scholar
  4. [4]
    M. Zembala andG.L. Asherson,Contact sensitivity in the mouse. V. The role of macrophage cytophilic antibody in passive transfer and the effect of trypsin and anti-gamma globulin serum, Cell. Immun.1, 276–289 (1970).CrossRefGoogle Scholar
  5. [5]
    R.K. Gershon, P.W., Askenase andM.D. Gershon,Requirement of vasoactive amines for production of delayed-type hypersensitivity skin reactions, J. exp. Med.142, 732–747 (1975).CrossRefPubMedGoogle Scholar
  6. [6]
    C.S. Asherson, W.R. Thomas andM.C. Watkins,Reaginic antibody produced in mice with contact sensitivity, J. exp. Med.144, 1386–1391 (1976).CrossRefPubMedGoogle Scholar
  7. [7]
    P.W. Askenase, Role of basophils, mast cells and vasoamines in hypersensitivity reactions with a delayed time course, Prog. Allergy23, 199–320 (1977).PubMedGoogle Scholar
  8. [8]
    P. Phanuphak, J.W. Moorhead andH.N. Claman,Tolerance and contact sensitivity to DNCB in mice. I. In vivo detection by ear swelling and correlation with in vitro cell stimulation, J. Immun. 112, 116–123 (1974).Google Scholar
  9. [9]
    J.P. Tarayre andH. Lauressergues,Comparison of the effect of phenylbutazone, desonide and cyclophosphamide on four types of experimental pleurisy, J. Pharm. Pharmac.32, 408–412 (1980).Google Scholar
  10. [10]
    J.P. Tarayre, M. Barbara, G. Villanova, M. Bru andH. Lauressergues,Modification by various drugs of two models of arthus reaction in the rat, Arzneimittel-Forsch.32, 1, 45–49 (1982).Google Scholar
  11. [11]
    E.W. Barry andR. Woodford,The comparative bioavailability of proprietary topical corticosteroid preparations: vasoconstrictor assays on thirty creams and gels, Br. J. Derm.91, 323–328 (1974).Google Scholar
  12. [12]
    E.P. Benditt, S. Schiller, H. Wong andA. Dorfman,Influence of ACTH and cortisone upon alteration in capillary permeability induced by hyaluronidase in rats. Proc. Soc. exp. Biol. Med.75, 782–784 (1950).PubMedGoogle Scholar
  13. [13]
    M.K. Church andP. Miller,Time courses of the anti-anaphylactic and anti-inflammatory effects of dexamethasone in the rat and mouse, Br. J. Pharmac. Chemother.62, 481–486 (1978).Google Scholar
  14. [14]
    N.W. Greaves, J. Sondergaard andMcW. Donald-Gibson,Recovery of prostaglandins in human cutaneous inflammation, Br. med. J.ii, 258–260 (1971).Google Scholar
  15. [15]
    M.E. Goldyne, R.K. Winkelmann andR.J. Ryan,Prostaglandin activity in human cutaneous inflammation: Detection by radio immunoassay, Prostaglandins4, 737–742 (1973).PubMedGoogle Scholar
  16. [16]
    K. Polak,Recent trends in the immunology of contact sensitivity, I, Contact Derm.4, 249–255 (1978).PubMedGoogle Scholar
  17. [17]
    J.B. Peter,Cytotoxin(s) produced by human lymphocytes: Inhibition by anti-inflammatory steroids and anti-malarial drugs, Cell. Immun.2, 199–202 (1971).CrossRefGoogle Scholar
  18. [18]
    W.J. Casey andC.E. McCall,Suppression of cellular interactions of delayed hypersensitivity by corticosteroids, Immunology21, 225–231 (1971).Google Scholar
  19. [19]
    J.E. Balow andA.S. Rosenthal,Glucocorticoid suppression of macrophage migration inhibitory factor, J. exp. Med.137, 1031–1041 (1973).CrossRefPubMedGoogle Scholar
  20. [20]
    W.L. Weston, H.N. Claman andG.G. Krueger,Site of action of cortisol in cellular immunity, J. Immun.110, 880–883 (1973).PubMedGoogle Scholar
  21. [21]
    J.P. Tarayre andH. Lauressergues,Anti-inflammatoires non steroidiens et libérateur d'histamine 48/80, Annls pharm. fr.36, 61–66 (1978).Google Scholar
  22. [22]
    K.F. Swingle, M.J. Reiter andD.M. Schwartzmiller,Comparison of croton oil and cantharidin induced inflammations of the mouse ear and their modification by topically applied drugs, Archs int. Pharmacodyn. Thér.254, 168–176 (1981).Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • J. P. Tarayre
    • 1
  • H. Lauressergues
    • 1
  1. 1.Department of PharmacologyP. Fabre Research CentreCastresFrance

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