Agents and Actions

, Volume 25, Issue 3–4, pp 231–233 | Cite as

Neuronal and behavioural consequences of chemical inflammation of rat urinary bladder

  • S. B. McMahon
Article

Abstract

Exposure of the urinary bladder of rats to chemical irritants such as turpentine produces a long lasting inflammatory response. Chemosensitive primary afferent fibres supplying the bladder are excited by the irritants. Dorsal horn cells in L6, S1 are also excited, and show slowly developing and persistent increases in ongoing activity, responses to electrical stimulation of vesical afferents and distension of the bladder. These changes may provide an explanation for the sensory and reflex disturbances that occur in cystitis in man.

Keywords

Inflammatory Response Electrical Stimulation Urinary Bladder Behavioural Consequence Dorsal Horn 

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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • S. B. McMahon
    • 1
  1. 1.St. Thomas' Hospital Medical SchoolLondonUK

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