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, Volume 7, Issue 1, pp 171–173 | Cite as

Ethanol and tolerated doses ofAmanita phalloides protect against lethal doses of the mushroom

  • G. L. Floersheim
Models in Toxicology

Abstract

Single tolerated doses of a lyophilizate fromAmanita phalloides (APL) failed to increase the survival rate of mice after the LD90 of the mushroom. Also, pretreatment with large doses of ethanol did not protect against lethal doses of APL. However, with combined administration of single tolerated doses of APL and of ethanol, the survival rate of mice after a lethal challenge with APL was increased from 13% to up to 100%. Both ethanol and APL potentiated the effect of barbiturate narcosis, but the combined pretreatment was not more effective. The protection against APL afforded by the combined regimen may be due to inhibition of activating hepatic microsomal enzymes, but biochemical studies are needed to support this hypothesis.

Keywords

Survival Rate Large Dose Barbiturate Biochemical Study Lethal Dose 

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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • G. L. Floersheim
    • 1
  1. 1.Dekanat der Medizinischen Fakultät der Universität BaselBasel

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