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, Volume 7, Issue 1, pp 133–144 | Cite as

AHR-5850: A potent anti-inflammatory compound

  • Lawrence F. Sancilio
  • Donna L. Reese
  • Stephen Cheung
  • Reevis S. Alphin
Immunosuppression and Inflammation

Abstract

AHR-5850 is a non-steroidal anti-inflammatory compound possessing antipyretic and analgesic properties. AHR-5850 was 16.4 and 22.8 times more potent than phenylbutazone in suppressing acute (Evans blue-carrageenan pleural effusion) and chronic (adjuvant-induced arthritis) inflammation, respectively. The analgesic activity of AHR-5850 was 43 times that of acetylsalicylic acid in the Randall-Selitto assay, and 156 and 56.3 times more potent than phenylbutazone in the acetylcholine-induced nociceptive response in dogs, respectively. Single-dose studies showed that AHR-5850 produced less gastric irritation than acetylsalicylic acid when applied topically to the exposed gastric mucosa of cats or when administered orally to rats and dogs. Upon subchronic oral administration to rats, the therapeutic ratio of AHR-5850 was twice that of phenylbutazone. This was based on the ratio of its potency relative to phenylbutazone in producing intestinal lesions to its anti-inflammatory potency relative to phenylbutazone in the adjuvant-induced arthritis.

Keywords

Arthritis Oral Administration Pleural Effusion Gastric Mucosa Acetylsalicylic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • Lawrence F. Sancilio
    • 1
  • Donna L. Reese
    • 1
  • Stephen Cheung
    • 1
  • Reevis S. Alphin
    • 1
  1. 1.Pharmacological Research LaboratoryA. H. Robins Co., Inc.Richmond

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