Agents and Actions

, Volume 7, Issue 1, pp 57–61 | Cite as

The modulation of histamine release by alpha-Adrenoceptors: Evidences in murine neoplastic mast cells

  • F. Moroni
  • R. Fantozzi
  • Emanuela Masini
  • P. F. Mannaioni
Selected Papers Given at the ‘5th Annual Meeting of the European Branch of the Histamine Club’, Paris, 6–8 May 1976


Murine neoplastic mast cells which have been loaded with exogenous labelled histamine, released14C-histamine when exposed to increasing concentrations of phenylephrine and noradrenaline. Adrenaline was only slightly effective, while isoprenaline and dibutyryl-cyclic-AMP were fully inactive. The release of histamine evoked by alpha-adrenergic agonists was antagonized by phentolamine, and left unchanged by practolol and cocaine. It is concluded that alpha-adrenoceptors may be valuable in evoking histamine release by murine neoplastic mast cells.


Cocaine Mast Cell Histamine Noradrenaline Adrenaline 
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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • F. Moroni
    • 1
  • R. Fantozzi
    • 1
  • Emanuela Masini
    • 1
  • P. F. Mannaioni
    • 1
  1. 1.Department of Pharmacology and Toxicology, School of MedicineUniversity of FlorenceFlorenceItaly

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