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SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells

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SV40 virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.

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  1. Acknowledgments. We want to thank Dr Peter K. Müller for providing us with the cells. The excellent technical assistance of Mrs Ivana Brega is gratefully acknowledged. This work was supported by grants of the Consiglio Nazionale delle Ricerche (CNR), ‘Progetto Bilaterale’ N.84.01896.04 and ‘Progetto Finalizzato’ N.83.00901.96, and by Grants of the Deutsche Forschungsgemeinschaft (DFG): Ho 740 and Po 189/3-1.

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Authors and Affiliations

  1. Istituto Nazionale per la Ricerca sul Cancro, I-16132, Genova, Italy

    A. Albini, G. Allavena, H. Richter, B. F. Pontz, S. Parodi & L. Santi

  2. Max-Planck-Institut für Biochemie, D-8033, Martinsried, Germany

    A. Albini, G. Allavena, H. Richter, B. F. Pontz, S. Parodi & L. Santi

  3. Kinderklinik der Universität, D-6500, Mainz, Germany

    A. Albini, G. Allavena, H. Richter, B. F. Pontz, S. Parodi & L. Santi

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  1. A. Albini
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  2. G. Allavena
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  3. H. Richter
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  4. B. F. Pontz
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  5. S. Parodi
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  6. L. Santi
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Albini, A., Allavena, G., Richter, H. et al. SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells. Experientia 41, 1591–1593 (1985). https://doi.org/10.1007/BF01964822

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  • DOI: https://doi.org/10.1007/BF01964822

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