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Induction of IgG1 and IgE responses to protein-conjugated and unconjugated β-lactam antibiotics in the mouse-efficacy of Freund's complete adjuvant

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Summary

One or two injections two weeks apart of protein-conjugated penicillin G, cephalothin or cefmetazole emulsified with Freund's complete adjuvant were quite effective in producing anti-antibiotic antibodies of the IgE as well as of the IgG1 class in mice. Long-lasting and boostable production of both antibody classes was also obtained against unconjugated cephalothin or cefmetazole, though the positivity depended on the mouse strain.

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Authors and Affiliations

  1. Shionogi Research Laboratories, Shionogi & Co. Ltd, Fukushima-ku, 553, Osaka, Japan

    M. Harada, A. Watanabe, M. Matsumoto & M. Takeuchi

Authors
  1. M. Harada
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  2. A. Watanabe
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  3. M. Matsumoto
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  4. M. Takeuchi
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Harada, M., Watanabe, A., Matsumoto, M. et al. Induction of IgG1 and IgE responses to protein-conjugated and unconjugated β-lactam antibiotics in the mouse-efficacy of Freund's complete adjuvant. Experientia 41, 1584–1585 (1985). https://doi.org/10.1007/BF01964818

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  • DOI: https://doi.org/10.1007/BF01964818

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