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Cytotoxicity of human peripheral blood T-lymphocyte clones activated by hepatitis B virus surface antigen

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Summary

The present studies examined the cytotoxic activities of peripheral blood lymphocytes (PBL) from volunteers with (sero-positive) and without (sero-negative) circulating antibodies to hepatitis B virus surface antigen before and 30 days after vaccination with hepatitis B virus surface antigen (HBsAg). Long-term culture of monospecific hepatitis B surface (HBsAg)-responsive T-lymphocytes were isolated and grown in large numbers. The mechanism of T-cell mediated cytolysis, and the identification of the carbohydrate determinants on the surface of these effector cells responsible for the killing effect, are being examined.

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Authors and Affiliations

  1. Department of medicine, Stritch School of Medicine, Loyola University Medical Center, 60901, Maywood, Illinois, USA

    A. A. Hakim

  2. Department of Histology, School of Dentistry, Loyola University Medical Center, Box 50, 60901, Maywood, Illinois, USA

    A. A. Hakim

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  1. A. A. Hakim
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Hakim, A.A. Cytotoxicity of human peripheral blood T-lymphocyte clones activated by hepatitis B virus surface antigen. Experientia 41, 1579–1584 (1985). https://doi.org/10.1007/BF01964817

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  • DOI: https://doi.org/10.1007/BF01964817

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