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TRH analogue with C-terminal thioamide group. Synthesis, receptor binding, TSH-releasing activity and α-MSH-releasing activity

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Summary

A new TRH analogue containing a C-terminal thioamide group was synthesized. This peptide was shown to have receptor-binding affinity, and TSH- as well as α-MSH-releasing activities very similar to native TRH.

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Authors and Affiliations

  1. Institute of Chemistry, University of Gdańsk, Sobieskiego 18, 80952, Gdańsk, Poland

    M. Kruszyński, G. Kupryszewski, U. Ragnarsson, M. Alexandrova, V. Strbak, M. C. Tonon & H. Vaudry

  2. Institute of Biochemistry, University of Uppsala, Biomedical Center, Box 576, S-751 23, Uppsala, Sweden

    M. Kruszyński, G. Kupryszewski, U. Ragnarsson, M. Alexandrova, V. Strbak, M. C. Tonon & H. Vaudry

  3. Institute of Experimental Endocrinology, Centre of Physiological Sciences, Vlarska 3, CS-80936, Czechoslovakia

    M. Kruszyński, G. Kupryszewski, U. Ragnarsson, M. Alexandrova, V. Strbak, M. C. Tonon & H. Vaudry

  4. Laboratory of Molecular Endocrinology, University of Rouen, Box 67, F-76130, Mont-Saint-Aignan, France

    M. Kruszyński, G. Kupryszewski, U. Ragnarsson, M. Alexandrova, V. Strbak, M. C. Tonon & H. Vaudry

Authors
  1. M. Kruszyński
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  2. G. Kupryszewski
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  3. U. Ragnarsson
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  4. M. Alexandrova
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  5. V. Strbak
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  6. M. C. Tonon
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  7. H. Vaudry
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Additional information

Acknowledgments. This work was supported by the Swedish Natural Science Research Council (K-KU 3020-112) and the Polish Academy of Sciences (Research Grant No. MR I 12.1.6.1).

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Kruszyński, M., Kupryszewski, G., Ragnarsson, U. et al. TRH analogue with C-terminal thioamide group. Synthesis, receptor binding, TSH-releasing activity and α-MSH-releasing activity. Experientia 41, 1576–1577 (1985). https://doi.org/10.1007/BF01964815

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  • DOI: https://doi.org/10.1007/BF01964815

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