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Experientia

, Volume 41, Issue 12, pp 1568–1571 | Cite as

Quantitative differences in the pharmacological effects of (+)- and (−)-cathinone

  • R. Gugelmann
  • M. von Allmen
  • R. Brenneisen
  • H. Porzig
Short Communications

Summary

The optically pure isomers of cathinone were prepared by separating synthetic cathinone racemate and used to study central and peripheral effects of these indirect sympathomimetics in rats and guinea pigs. The (−)-isomer was significantly more potent than the (+)-isomer in stimulating locomotor activity whereas no difference was observed with respect to their cardiac effects. In analogy to observations with (+)- and (−)-amphetamine such variable isomer discrimination may be due to different stereoselectivities of amine uptake mechanisms in the target tissues.

Key words

(+)-Cathinone (−)-cathinone cardiac stimulation locomotor activity 

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Copyright information

© Birkhäuser Verlag 1985

Authors and Affiliations

  • R. Gugelmann
    • 1
  • M. von Allmen
    • 1
  • R. Brenneisen
    • 1
  • H. Porzig
    • 1
  1. 1.Pharmakologisches InstitutUniversität BernBernSwitzerland

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