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Effects of acetaldehyde and/or ethanol on neutral amino acid transport systems in microvillous brush border membrane vesicles prepared from human placenta

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At 20 mM of acetaldehyde, the activities of three transport systems of L-alanine distinguished by the difference in their cation dependence, namely 1) Na+-specific, 2) Li+-dependent, and 3) Na+-independent systems, were significantly reduced in a similar manner. Only the Li+-dependent system was selectively inhibited at toxic concentrations of acetaldehyde and ethanol.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Nagoya University Branch Hospital, Higashi-ku, 461, Nagoya, Japan

    M. Asai & O. Narita

  2. Department of Perinatology, Institute for Developmental Research, Aichi Prefecture Colony, 480-03, Kasugai, Aichi, Japan

    S. Kashiwamata

Authors
  1. M. Asai
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  2. O. Narita
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  3. S. Kashiwamata
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Asai, M., Narita, O. & Kashiwamata, S. Effects of acetaldehyde and/or ethanol on neutral amino acid transport systems in microvillous brush border membrane vesicles prepared from human placenta. Experientia 41, 1566–1568 (1985). https://doi.org/10.1007/BF01964810

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  • DOI: https://doi.org/10.1007/BF01964810

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