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Stress by restraining potentiates morphine catalepsy in rats

Summary

Restraint-induced stress potentiated morphine catalepsy in rats. This potentiation was partially antagonized by pharmacologic treatments decreasing central serotonin, acetylcholine, prostaglandins and by naloxone. Selective increase in central dopamine also inhibited the potentiation.

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Acknowledgments. SKB is an ECFMG Senior Faculty Fellow from the Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Partial research support by the Dakota State Aerie Fraternal Order of Eagles is gratefully acknowledged.

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Bhattacharya, S.K., Parmar, S.S. Stress by restraining potentiates morphine catalepsy in rats. Experientia 41, 1542–1543 (1985). https://doi.org/10.1007/BF01964797

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  • DOI: https://doi.org/10.1007/BF01964797

Key words

  • Immobilization-induced stress
  • morphine catalepsy
  • rat brain
  • serotonin
  • acetylcholine
  • prostaglandins
  • dopamine
  • naloxone