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Frequency-dependent effect of verapamil on rat soleus muscle

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Summary

In the presence of verapamil (0.1 mM) rat soleus muscle fibers failed to generate action potentials with overshoots. In fibers with their Vm set to a local level of −90 mV, verapamil produces a gradual reduction in the amplitude of the repetitive action potentials; this effect is more pronounced at high rates of stimulation (100 Hz). Our results suggest a local anesthetic action of this drug that could contribute with its calcium channel blocking effect to the diminished mechanical tension observed in the presence of the drug.

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Authors and Affiliations

  1. Instituto de Investigaciones Médicas, Donato Alvarez 3150, 1427, Buenos Aires, Argentina

    B. A. Kotsias & S. Muchnik

Authors
  1. B. A. Kotsias
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  2. S. Muchnik
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Additional information

Acknowledgments. We thank A. Losavio and M. Stefanolo for technical assistance. This work was supported by grants from CONICET and SUBCYT, Buenos Aires, Argentina and Muscular Dystrophy Association, USA.

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Kotsias, B.A., Muchnik, S. Frequency-dependent effect of verapamil on rat soleus muscle. Experientia 41, 1538–1540 (1985). https://doi.org/10.1007/BF01964795

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