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Agents and Actions

, Volume 29, Issue 1–2, pp 56–58 | Cite as

Thein vivo andin vitro anti-inflammatory activity of CD271: A new retinoid-like modulator of cell differentiation

  • C. Hensby
  • D. Cavey
  • M. Bouclier
  • A. Chatelus
  • D. Algate
  • J. Eustache
  • B. Shroot
Lipid Mediators and Anti-Inflammatory Molecules

Conclusion

CD 271 possesses a potent anti- inflammatory activity in a large number of models particularly when compared with known reference anti-inflammatory agents. Retinoids (all-trans retinoic acid, 13 cis retinoic acid and Etretinate) show very weak or no activity.

In view of these properties of CD 271, an enhanced therapeutic value can be anticipated in the treatment of skin diseases such as acne and psoriasis.

Keywords

Cell Differentiation Psoriasis Retinoic Acid Acne Retinoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    C. N. Hensby, J. Eustache, B. Shroot, M. Bouclier, A. Chatelus and B. Luginbuhl,Anti-inflammatory aspects of systemic and topically applied retinoids. Agents and Actions21, 238–240 (1987).PubMedGoogle Scholar
  2. [2]
    D. Cavey,In vitro models for the evaluation of anti-inflammatory drug action in the skin. InNon steroidal Anti-inflammatory Drugs. Pharmacology and the skin, vol. 2. (Eds. N. Lowe and C. Hensby) pp. 44–48, Karger 1989.Google Scholar
  3. [3]
    M. Bouclier, A. Chatelus and C. Hensby,In vivo animal models for the evaluation of anti-inflammatory drug action in the skin. InNon steroidal Anti-inflammatory Drugs. Pharmacology and the skin, vol. 2. (Eds. N. Lowe and C. Hensby) pp. 118–135, Karger 1989.Google Scholar

Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • C. Hensby
    • 1
  • D. Cavey
    • 1
  • M. Bouclier
    • 1
  • A. Chatelus
    • 1
  • D. Algate
    • 2
  • J. Eustache
    • 1
  • B. Shroot
    • 1
  1. 1.Centre International de Recherches Dermatologiques (CIRD) Sophia-AntipolisValbonneFrance
  2. 2.Department of pharmacologyHuntingdon Research Centre (HRC)HuntingdonEngland

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