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, Volume 29, Issue 1–2, pp 52–53 | Cite as

15-HETE inhibits leukotriene B4 formation and synovial cell proliferation in experimental arthritis

  • T. Herlin
  • K. Fogh
  • E. S. Hansen
  • A. Andreasen
  • V. Knudsen
  • T. B. Henriksen
  • C. Bunger
  • K. Kragballe
Lipid Mediators and Anti-Inflammatory Molecules

Keywords

Arthritis Cell Proliferation Synovial Cell Experimental Arthritis Synovial Cell Proliferation 

References

  1. [1]
    T. Herlin, K. Fogh, H. Ewald, E. S. Hansen, V. F. Knudsen, I. Holm, K. Kragballe and C. Bunger,Changes in lipoxygenase products from synovial fluid in carragheenan induced arthritis in dogs. APMIS96, 601 604 (1988).Google Scholar
  2. [2]
    J. Y. Vanderhoek, R. W. Bryant and J. M. Bailey,Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. J. Biol. Chem.255, 10064–10066 (1980).PubMedGoogle Scholar
  3. [3]
    T. Ternowitz, K. Fogh and K. Kragballe,15-hydroxy-eicosatetraenoic acid (15-HETE) speeifically inhibits LTB 4-induced chemotaxis of human neutrophils. Skin Pharmacology1, 93 99 (1988).Google Scholar
  4. [4]
    K. Fogh, H. Søgaard, T. Herlin and K. Kragballe,Improvement of psoriasis vulgaris after intralesional injections of 15-hydroxy-eicosatetraenoic acid (15-HETE). J. Am. Acad. Dermatol.18, 279–285 (1988).PubMedGoogle Scholar
  5. [5]
    K. Fogh, E. S. Hansen, T. Herlin, V. Knudsen, T. B. Henriksen, H. Ewald, C. Bunger and K. Kragballe,15-hydroxyeicosatetraenoic acid (15-HETE) inhibits carragheenan-induced experimental arthritis and reduces synovial fluid leukotriene B 4 (LTB 4). Prostaglandins37, 213 228 (1989).Google Scholar

Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • T. Herlin
    • 1
  • K. Fogh
    • 1
  • E. S. Hansen
    • 1
  • A. Andreasen
    • 1
  • V. Knudsen
    • 1
  • T. B. Henriksen
    • 1
  • C. Bunger
    • 1
  • K. Kragballe
    • 1
  1. 1.Department of Rheumatology, Orthopaedic Hospital, Department of Dermatology, Marselisborg Hospital, Institute of Experimental Clinical ResearchUniversity of AarhusAarhus CDenmark

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