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Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment ofPneumocystis carinii pneumonia

European Journal of Clinical Microbiology and Infectious Diseases volume 10, pages 207–210 (1991)Cite this article

Abstract

Mild to moderately severePneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderatePneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.

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Affiliations

  1. Department of Internal Medicine, Department of Infectious Diseases, Rudolf Virchow University Hospital (Wedding), Freie Universität Berlin, Augustenburger Platz 1, D-1000, Berlin 65, FRG

    B. Ruf, I. Rohde & H. D. Pohle

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  1. B. Ruf
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  2. I. Rohde
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  3. H. D. Pohle
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Ruf, B., Rohde, I. & Pohle, H.D. Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment ofPneumocystis carinii pneumonia. Eur. J. Clin. Microbiol. Infect. Dis. 10, 207–210 (1991). https://doi.org/10.1007/BF01964466

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  • DOI: https://doi.org/10.1007/BF01964466

Keywords

  • Clinical Trial
  • Internal Medicine
  • Pneumonia
  • Treatment Regimen
  • Severe Case