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Clindamycin and primaquine as primary treatment for mild and moderately severePneumocystis carinii pneumonia in patients with AIDS

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Abstract

The combination of clindamycin and primaquine was investigated as primary treatment for mild or moderately severePneumocystis carinii pneumonia (alveolar-arterial oxygen gradient <40 torr) in 36 AIDS patients. All patients were treated with primaquine 30 mg (base) orally for 21 days. The first 22 patients were treated with clindamycin 900 mg i.v. q8h for the first 10 days, followed by clindamycin 450 mg q6h orally for 11 days. Twenty of these 22 patients (91 %) showed a marked clinical response by day 7. Four patients were later withdrawn from the study due to toxicity. An additional 14 patients were treated with an entirely oral regimen of clindamycin and primaquine. Thirteen of the 14 patients (93 %) showed a marked therapeutic response and 12 (86 %) successfully completed treatment. The combination of clindamycin and primaquine appears to be an effective and well-tolerated treatment for mild to moderately severePneumocystis carinii pneumonia in AIDS patients.

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References

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Authors and Affiliations

  1. Indiana University School of Medicine, 1633 North Capitol #700, 46202, Indianapolis, IN, USA

    J. R. Black

  2. Treatment Research Program, Division of AIDS, NIAID, Bethesda, MD, USA

    J. Feinberg

  3. Northwestern University Medical School, Chicago, IL, USA

    R. L. Murphy

  4. Ohio State University, Columbus, OH, USA

    R. J. Fass

  5. Case Western Reserve University, Cleveland, OH, USA

    J. Carey

  6. University of Southern California, Los Angeles, CA, USA

    F. R. Sattler

Authors
  1. J. R. Black
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  2. J. Feinberg
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  3. R. L. Murphy
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  4. R. J. Fass
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  5. J. Carey
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  6. F. R. Sattler
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Black, J.R., Feinberg, J., Murphy, R.L. et al. Clindamycin and primaquine as primary treatment for mild and moderately severePneumocystis carinii pneumonia in patients with AIDS. Eur. J. Clin. Microbiol. Infect. Dis. 10, 204–207 (1991). https://doi.org/10.1007/BF01964465

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  • DOI: https://doi.org/10.1007/BF01964465

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